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Titolo:
NK CELL-RECEPTOR GENE OF THE KIR FAMILY WITH 2 IG DOMAINS BUT HIGHESTHOMOLOGY TO KIR RECEPTORS WITH 3 IG DOMAINS
Autore:
SELVAKUMAR A; STEFFENS U; DUPONT B;
Indirizzi:
SLOAN KETTERING INST CANC RES,PROGRAM IMMUNOL,1275 YORK AVE NEW YORK NY 10021
Titolo Testata:
Tissue antigens
fascicolo: 4-I, volume: 48, anno: 1996,
pagine: 285 - 294
SICI:
0001-2815(1996)48:4-I<285:NCGOTK>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; H-2-DEFICIENT LYMPHOMA VARIANTS; HLA-C MOLECULES; MULTIGENE FAMILY; LINE; RECOGNITION; CLONES; LY-49; ASSOCIATION; REJECTION;
Keywords:
KILLER CELL INHIBITORY RECEPTORS; CDNA; NATURAL KILLER CELLS; PCR-SSP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
A. Selvakumar et al., "NK CELL-RECEPTOR GENE OF THE KIR FAMILY WITH 2 IG DOMAINS BUT HIGHESTHOMOLOGY TO KIR RECEPTORS WITH 3 IG DOMAINS", Tissue antigens, 48(4-I), 1996, pp. 285-294

Abstract

The killer cell inhibitory receptors (KIRs) are surface glycoproteinsexpressed by natural killer (NK) cells and some T cells. They recognize polymorphic human HLA class I molecules. Two families of KIRs have been identified and named p58 and p70. The p58 family of genes encode type I membrane proteins with two extracellular immunoglobulin (Ig) domains, while the p70 genes have three Ig domains. We here report the cloning and characterization of a novel KIR cDNA obtained from tumor cell lines with NK reactivity (YT and NK-92). This gene is also expressed in the normal cell line NK 3.3 and in NK cells obtained from some but not all normal donors. The clone, KIR103AS, has an open reading frame consistent with a KIR with two extracellular Ig domains, a transmembrane region and a 114 amino acid long cytoplasmic domain containing a single src homology 2 (SH2) binding motif. The membrane distal Ig domain of KIR103AS has highest homology with the first Ig domain of p70 KIRs and differs significantly from the first Ig domain of p58 KIRs. Thesecond, membrane proximal Ig domain of KIR103AS has similar and high homology with the membrane proximal Ig domains of both p70 and p58 KIRs. The extracellular domains of KIR103AS therefore share characteristic features with both p70 and p58 genes: the domain structure is identical to p58 KIRs but the sequence homology matches closely with p70 KIRs. The putative transmembrane and cytoplasmic domains are distinctly different from all previously reported KIR cDNAs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 19:48:47