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Titolo:
BONE-MINERAL DENSITY AND BONE MARKERS IN RELATION TO VITAMIN-D-RECEPTOR GENE POLYMORPHISMS IN CHINESE MEN AND WOMEN
Autore:
TSAI KS; HSU SHJ; CHENG WC; CHEN CK; CHIENG PU; PAN WH;
Indirizzi:
NATL TAIWAN UNIV HOSP,DEPT LAB MED,7 CHUNG SHAN S RD TAIPEI 100 TAIWAN NATL TAIWAN UNIV,COLL MED,DEPT LAB MED TAIPEI 10764 TAIWAN NATL TAIWAN UNIV,COLL MED,GRAD INST MED TECHNOL TAIPEI 10764 TAIWAN NATL TAIWAN UNIV,COLL MED,DEPT RADIOL TAIPEI 10764 TAIWAN ACAD SINICA,INST BIOMED SCI BEIJING 100864 PEOPLES R CHINA
Titolo Testata:
Bone
fascicolo: 5, volume: 19, anno: 1996,
pagine: 513 - 518
SICI:
8756-3282(1996)19:5<513:BDABMI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTMENOPAUSAL WOMEN; OSTEOPOROSIS; TURNOVER; ALLELES; MASS; TWIN; DETERMINANTS; PREDICTION; GENOTYPES; SERUM;
Keywords:
VDRG POLYMORPHISM; BONE MARKERS; BMD; CHINESE; MEN; WOMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
K.S. Tsai et al., "BONE-MINERAL DENSITY AND BONE MARKERS IN RELATION TO VITAMIN-D-RECEPTOR GENE POLYMORPHISMS IN CHINESE MEN AND WOMEN", Bone, 19(5), 1996, pp. 513-518

Abstract

Whether vitamin D receptor gene (VDRG) polymorphism can be used as a predictor for bone turnover rate or bone mass remains controversial, Its role within various ethnic populations are also unsettled, We examined VDRG polymorphism using restrictive enzymes Bsm-I, Apa-I, and Taq-I in 155 men aged 22-88 and 113 premenopausal women aged 40-53, The bone mineral density (BMD) of the vertebrae (L2-4), proximal femur, and total body bone mineral content (tb-BMC) (women only), as well as urinary N-terminal crosslinked fragment of type I collagen (NTX), serum osteocalcin, bone isozyme of alkaline phosphatase, and caboxyterminal propeptide of type I procollagen levels were measured, Chinese men and women exhibited a low prevalence for B (absence of Bsm-I restriction site) phenotypes than white and Japanese, Within the tested samples there were 0.4% BE homozygotes, 6.7% Bb heterozygotes, and 93% bb homozygotes, The distributions of Apa-I polymorphism (9.0% AA, 42.5% Aa, and 48.5% aa) also differed from those reported for the white populations, Most of the Chinese men and women were TT homozygous (96.6%), A comparison of actual values and values adjusted for age and weight of tb-BMCand BMD at the lumbar spine, Trochanter, Ward's triangle, and femoralneck showed no significant difference among three subgroups in each of the three sets of polymorphism, Furthermore, the actual values and adjusted values (adjusted for age) of the four bone markers, respectively, showed no significant differences, We conclude that given the verylow prevalence of the suspected high risk genotypes (B, A, and t), and the lack of difference among the polymorphic subgroups, VDRG polymorphism may not be an important determinant of the bone turnover rate and bone mass of Chinese men and women. (C) 1996 by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 01:03:28