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Titolo:
THE FUNCTION OF ADIPOCYTES IN THE BONE-MARROW STROMA - AN UPDATE
Autore:
GIMBLE JM; ROBINSON CE; WU X; KELLY KA;
Indirizzi:
OKLAHOMA MED RES FDN,IMMUNOBIOL & CANC PROGRAM,825 NE 13TH ST OKLAHOMA CITY OK 73104 UNIV OKLAHOMA,DEPT ZOOL NORMAN OK 73019 UNIV OKLAHOMA,HLTH SCI CTR,DEPT MICROBIOL & IMMUNOL OKLAHOMA CITY OK 73190 UNIV OKLAHOMA,HLTH SCI CTR,DEPT PATHOL OKLAHOMA CITY OK 73190 UNIV OKLAHOMA,HLTH SCI CTR,DEPT ORTHODONT OKLAHOMA CITY OK 73190
Titolo Testata:
Bone
fascicolo: 5, volume: 19, anno: 1996,
pagine: 421 - 428
SICI:
8756-3282(1996)19:5<421:TFOAIT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; WESTEN-BAINTON CELLS; GROWTH-FACTOR-BETA; OSTEOCLAST DIFFERENTIATION; OSTEOGENIC CELLS; 3RD COMPONENT; 1,25-DIHYDROXYVITAMIN D-3; HEMATOPOIETIC STROMA; MESENCHYMAL CELLS; B-LYMPHOPOIESIS;
Keywords:
ADIPOCYTES; ADIPOGENESIS; BONE MARROW STROMA; HEMATOPOIESIS; OSTEOGENESIS; OSTEOBLASTS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
109
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Gimble et al., "THE FUNCTION OF ADIPOCYTES IN THE BONE-MARROW STROMA - AN UPDATE", Bone, 19(5), 1996, pp. 421-428

Abstract

The adipocyte is the most abundant stromal cell phenotype in adult human bone marrow, Four hypotheses may explain their function, First, adipocytes may serve a passive role, simply occupying excess space in the bone marrow cavity, Second, they may play an active role in systemiclipid metabolism, Third, adipocytes may provide a localized energy reservoir in the bone marrow, Or fourth, marrow adipocytes may contribute directly to the promotion of hematopoiesis and influence osteogenesis, This article reviews recent findings concerning bone marrow adipocyte morphology and physiology, the transcriptional and cytokine mechanisms regulating their differentiation, and the interrelationships existing between bone marrow adipocytes, hematopoiesis, and osteogenesis, Overall, these data lend support to a ''plastic'' model of bone marrow stromal cell differentiation; adipocytes may share common functions with stromal stem cells, osteoblasts, and hematopoietic supportive cells, (C) 1996 by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 08:18:07