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Titolo:
POLYSYNAPTIC POTENTIATION IN THE LATERAL SEPTUM FOLLOWING STIMULATIONOF THE FIMBRIA IN ANESTHETIZED RATS
Autore:
GARCIA R; TOCCO G; BAUDRY M; THOMPSON R;
Indirizzi:
UNIV BORDEAUX 1,LAB NEUROSCI COMPORTEMENTALES & COGNIT,CNRS URA 339,1AVE FAC F-33405 TALENCE FRANCE UNIV SO CALIF,NEUROSCI PROGRAM LOS ANGELES CA 90089
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 737, anno: 1996,
pagine: 169 - 174
SICI:
0006-8993(1996)737:1-2<169:PPITLS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; NEURONS; MICE;
Keywords:
SYNAPTIC POTENTIATION; LONG-TERM POTENTIATION; FIMBRIA; LATERAL SEPTUM; CA3; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
R. Garcia et al., "POLYSYNAPTIC POTENTIATION IN THE LATERAL SEPTUM FOLLOWING STIMULATIONOF THE FIMBRIA IN ANESTHETIZED RATS", Brain research, 737(1-2), 1996, pp. 169-174

Abstract

In anesthetized rats, electrical stimulation of fimbria fibers evoked, in the ipsilateral lateral septum (LS), a field potential consistingof two negative components: an initial negativity (N-2-3 complex wave) of high amplitude at 6.7 ms (+/-0.8 ms; peak latency) and a slow negative wave (N4 wave) of small amplitude at 14.4 ms (+/-2.4 ms). The N-2-3 complex wave represents the monosynaptic activation of LS neurons while the N4 wave corresponds to polysynaptic activation of neurons inthe mediolateral part of the LS. In this study, we investigated the effects of high-frequency stimulation of fimbria fibers on LS field potentials and compared them with those observed in the CA3 area. Tetanicstimulation of the fimbria did not change the characteristics of the N-2-3 wave but induced a long-lasting increase in amplitude and slope of the N4 wave. A positive correlation was found between the magnitudeof CA3 LTP and lateral septal polysynaptic potentiation of the N4 component. These results indicate that patterns of stimulation delivered to the same input fibers (fimbria fibers) produce similar changes in apolysynaptic input to the LS and in a monosynaptic input to the CA3 and emphasize the complexity of signal processing in serial networks.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 02:47:19