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Titolo:
DETERMINATION OF MEFENAMIC-ACID AND PARACETAMOL BY FIRST DERIVATIVE SPECTROPHOTOMETRY
Autore:
TORAL MI; RICHTER P; ARAYA E; FUENTES S;
Indirizzi:
UNIV CHILE,FAC SCI,DEPT CHEM,POB 653 SANTIAGO COMPOSTE SPAIN
Titolo Testata:
Analytical letters
fascicolo: 15, volume: 29, anno: 1996,
pagine: 2679 - 2689
SICI:
0003-2719(1996)29:15<2679:DOMAPB>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHARMACEUTICAL PREPARATIONS; LIQUID-CHROMATOGRAPHY; FORMULATIONS; IRON;
Keywords:
MEFENAMIC ACID; PARACETAMOL DETERMINATION; SIMULTANEOUS DETERMINATION; DERIVATIVE SPECTROPHOTOMETRY; ZERO-CROSSING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
M.I. Toral et al., "DETERMINATION OF MEFENAMIC-ACID AND PARACETAMOL BY FIRST DERIVATIVE SPECTROPHOTOMETRY", Analytical letters, 29(15), 1996, pp. 2679-2689

Abstract

A direct and simple first derivative spectrophotometric method has been developed for the determination of mefenamic acid and paracetamol in pharmaceutical formulations. A methanolic hydrochloric acid solutionwas used as solvent for extracting the drugs from the formulations and subsequently the samples were evaluated directly by derivative spectrophotometry. Simultaneous determination of both drugs can be carried out using the zero-crossing and the graphical methods. The methods do not require simultaneous equations to be solved. The calibration graphs were linear in the ranges from 1.8x 10(-6) to 1.6 x 10(-4) M of mefenamic acid and from 4.1 x 10(-6) to 1.4 x 10(-4) M of paracetamol. Theingredients commonly found in commercial pharmaceutical formulations do not interfere. The proposed method was applied to the determinationof these drugs in tablets.

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Documento generato il 25/11/20 alle ore 04:31:08