Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
TONIC FACILITATION OF GLUTAMATE RELEASE BY PRESYNAPTIC N-METHYL-D-ASPARTATE AUTORECEPTORS IN THE ENTORHINAL CORTEX
Autore:
BERRETTA N; JONES RSG;
Indirizzi:
UNIV OXFORD,DEPT PHARMACOL,MANSFIELD RD OXFORD OX1 3QT ENGLAND UNIV OXFORD,DEPT PHARMACOL OXFORD OX1 3QT ENGLAND
Titolo Testata:
Neuroscience
fascicolo: 2, volume: 75, anno: 1996,
pagine: 339 - 344
SICI:
0306-4522(1996)75:2<339:TFOGRB>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NORADRENALINE RELEASE; HIPPOCAMPAL SLICES; CEREBRAL-CORTEX; NERVE-TERMINALS; RAT STRIATUM; RECEPTORS; NEURONS; RESPONSES; DOPAMINE;
Keywords:
ENTORHINAL CORTEX; NMDA; PRESYNAPTIC RECEPTORS; GLUTAMATE RELEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
N. Berretta e R.S.G. Jones, "TONIC FACILITATION OF GLUTAMATE RELEASE BY PRESYNAPTIC N-METHYL-D-ASPARTATE AUTORECEPTORS IN THE ENTORHINAL CORTEX", Neuroscience, 75(2), 1996, pp. 339-344

Abstract

N-Methyl-D-aspartate receptors are fundamental for neuronal plasticity and development in the CNS.(3,22) Most studies have examined postsynaptic roles of this receptor, but there are also indications for a presynaptic location and function.(6,18,23) Here, we provide electrophysiological evidence for the existence of presynaptic N-methyl-D-aspartate receptors which can tonically facilitate glutamate release in the CNS. The N-methyl-D-aspartate receptor antagonist 2-amino-5-phosphonopentanoate reduced the frequency, but not amplitude, of glutamate-mediated spontaneous excitatory postsynaptic currents in layer II neurons of the rat entorhinal cortex. This effect was also observed in the presence of tetrodotoxin and when postsynaptic N-methyl-D-aspartate receptors were blocked by dialysis with dizocilpine maleate. When extracellular calcium was replaced with strontium, 2-amino-5-phosphonopentanoate reduced the ''tail'' of spontaneous excitatory postsynaptic currents that followed an evoked excitatory postsynaptic current. Finally, there was a tendency for paired-pulse facilitation of excitatory postsynaptic currents evoked at short (50 ms) intervals with postsynaptic N-methyl-D-aspartate receptors blocked) to be reduced by 2-amino-5-phosphonopentanoate, although this did not reach significance. These data strongly support the presence of presynaptic N-methyl-D-aspartate autoreceptors which mag facilitate glutamate release in layer II of the entorhinal cortex. Copyright (C) 1996 IBRO.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 03:57:27