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Titolo:
ASSOCIATIONS BETWEEN HUMAN-LEUKOCYTE ANTIGEN TYPE AND NASOPHARYNGEAL CARCINOMA IN CAUCASIANS IN THE UNITED-STATES
Autore:
BURT RD; VAUGHAN TL; MCKNIGHT B; DAVIS S; BECKMANN AM; SMITH AG; NISPEROS B; SWANSON GM; BERWICK M;
Indirizzi:
FRED HUTCHINSON CANC RES CTR,HUTCHINSON SMOKING PREVENT PROJECT,DIV PUBL HLTH SCI SEATTLE WA 98104 FRED HUTCHINSON CANC RES CTR,DIV CLIN MED SEATTLE WA 98104 UNIV WASHINGTON,DEPT EPIDEMIOL,SCH PUBL HLTH & COMMUNITY MED SEATTLE WA 98195 UNIV WASHINGTON,DEPT BIOSTAT SEATTLE WA 98195 MICHIGAN STATE UNIV,COLL HUMAN MED,CTR CANC E LANSING MI 48824 YALE UNIV,DEPT EPIDEMIOL & PUBL HLTH NEW HAVEN CT 06520 MEM SLOAN KETTERING CANC RES CTR NEW YORK NY 10021
Titolo Testata:
Cancer epidemiology, biomarkers & prevention
fascicolo: 11, volume: 5, anno: 1996,
pagine: 879 - 887
SICI:
1055-9965(1996)5:11<879:ABHATA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; CIGARETTE-SMOKING; HODGKINS-DISEASE; RISK-FACTORS; HLA; LYMPHOMA; CHINESE; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
R.D. Burt et al., "ASSOCIATIONS BETWEEN HUMAN-LEUKOCYTE ANTIGEN TYPE AND NASOPHARYNGEAL CARCINOMA IN CAUCASIANS IN THE UNITED-STATES", Cancer epidemiology, biomarkers & prevention, 5(11), 1996, pp. 879-887

Abstract

A genetic component to nasopharyngeal carcinoma (NPC) has been suggested by associations of the malignancy with human leukocyte antigens (HLAs) in Southern Chinese populations, among which NPC is a major cancer, Data from other races are inconclusive, We have investigated associations between NPC and HLA antigens at the HLA-A, B, C, and DQ loci and alleles at the DRB1 locus in a population-based, multicenter investigation in the United States. Data from 82 cases and 140 controls are presented, making this the largest study population analyzing data fromCaucasians to date. HLA frequencies from study cases were also compared with external control groups from the 11th International Histocompatibility Workshop and the National Marrow Donor Program. Logistic regression methods were used to investigate the effects of the joint occurrence of multiple HLA types and to assay for differences in HLA-associated risk in different age groups. A meta-analysis was undertaken to compare and summarize our results with previously published findings, The meta-analysis found a protective association with A2 antigen in non-Chinese [odds ratio (OR), 0.63; P < 0.001], a protective association with All across all races (OR, 0.54; P < 0.001), and an increased riskassociated with B5 in Caucasians (OR, 2.81; P < 0.001). The present study also found independent associations, in a logistic regression model, between NPC and DRB11501 (OR, 0.33), DRB1*0405 (OR, 7.57), and Cw3 (OR, 0.42), although these data must be interpreted cautiously due to multiple-testing considerations. Associations were found to be more pronounced in younger patients for A2, A11, A28, B8, and B51.

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Documento generato il 12/07/20 alle ore 05:50:34