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Titolo:
CLASSIFICATION, OSCILLATORY AND ALTERNATING OSCILLATORY FIRING OF ALPHA(1) (FF) AND ALPHA(2)-MOTONEURONS (FR) IN PATIENTS WITH SPINAL-CORD LESION
Autore:
SCHALOW G; BERSCH U; ZACH GA; WARZOK R;
Indirizzi:
SWISS PARAPLEG CTR NOTTWIL,DEPT CLIN RES NOTTWIL SWITZERLAND UNIV GREIFSWALD,INST PATHOL GREIFSWALD GERMANY
Titolo Testata:
General physiology and biophysics
, volume: 15, anno: 1996, supplemento:, 1
pagine: 5 - 56
SICI:
0231-5882(1996)15:<5:COAAOF>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SACRAL NERVE ROOTS; DETRUSOR-SPHINCTERIC DYSSYNERGIA; FICTIVE LOCOMOTION; CENTRAL GENERATION; RENSHAW CELLS; AFFERENTS; MUSCLE; CAT; HINDLIMB; BLADDER;
Keywords:
PARAPLEGIA; SPINAL CANAL ANATOMY; NERVE FIBERS; CLASSIFICATION SCHEME; SINGLE-FIBER ACTION POTENTIAL; COMPOUND ACTION POTENTIAL; CONDUCTION VELOCITY; SPINAL OSCILLATOR; ALTERNATING OSCILLATORY FIRING;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
111
Recensione:
Indirizzi per estratti:
Citazione:
G. Schalow et al., "CLASSIFICATION, OSCILLATORY AND ALTERNATING OSCILLATORY FIRING OF ALPHA(1) (FF) AND ALPHA(2)-MOTONEURONS (FR) IN PATIENTS WITH SPINAL-CORD LESION", General physiology and biophysics, 15, 1996, pp. 5-56

Abstract

Single-nerve fibre action potentials (APs) were recorded extracellularly from sacral nerve roots of people with spinal cord lesion (patients with paraplegia). Single-fibre APs of certain fibres were identifiedby the conduction velocity and the AP waveform, and simultaneous impulse patterns were extracted from the summed impulse traffic and analysed with respect to spacio-temporal relationships. The velocity values of components of compound APs, induced by electrical nerve root stimulation or electrical intravesical stimulation, were similar to the group conduction velocity values obtained from single-nerve fibre APs of natural impulse traffic. When changing the root temperature in one casefrom 32 degrees C to 35.5 degrees C, the group conduction velocities changed in the following way: secondary muscle spindle afferents (SP2): 40m/s (32 degrees C) to 50 m/s (35.5 degrees C); bladder stretch afferents (S1): 31.3 to 40 m/s; bladder tension afferents (ST): 25 to 33.8 m/s; mucosal afferents (M): 12.5 to 13.8 m/s; alpha(1): -; alpha(2)-motoneurons: 40 to 50 m/s; alpha(3): 33 to 40 m/s. The group conduction velocities showed different temperature dependence apart from SP2 fibres and alpha(2)-motoneurons, which were therefore used for calibration. The distance between two Pacinian corpuscle (PC) receptors in a sacral dermatome of one paraplegic patient was calculated to be approximately 20 mm. A similar distance between PC receptors was found in a brain-dead individual. Receptor densities seem therefore to remain unchanged following spinal cord lesion. Motoneurons fired irregularly repeatedly with impulse trains. In paraplegics the oscillation periods and the interspike intervals of the impulse trains varied much more than observed for brain-dead and normal individuals. Motoneurons could therefore not always be identified by their pattern of oscillatory firing. Alternating long and short oscillation periods (T) could be measured in an oscillatory firing alpha(1) (T = 125 ms) and alpha(2)-motoneuron (T = 150 ms). In both cases the average difference between the alternating oscillation periods was 5 ms. Tremor, alternating long and short oscillation periods, cellular oscillator properties, and recurrent excitation and inhibition are discussed with respect to the oscillator theory of the functioning of the human central nervous system. Mathematical predictions from populations of interacting biological oscillatorsare compared to measurements on neuronal network data. The pathologicactivation of two-joint muscles following hemiplegia, cerebral palsy and partial spinal cord lesion is discussed with respect to the two coupling phases of the pre-motor spinal oscillator cycle per somatic nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:10:53