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Titolo:
IN-VITRO AND IN-VIVO RESULTS OF TRANSCATHETER MICROWAVE ABLATION USING FORWARD-FIRING TIP ANTENNA DESIGN
Autore:
LIEM LB; MEAD RH; SHENASA M; KERNOFF R;
Indirizzi:
STANFORD UNIV,CARDIAC ARRHYTHMIA & ELECTROPHYSIOL SECT,300 PASTEUR DR,ROOM H-2146 STANFORD CA 94305 STANFORD UNIV,DIV CARDIOVASC MED STANFORD CA 94305 SEQUOIA HOSP,DEPT CARDIOL REDWOOD CITY CA 00000 OCONNOR HOSP,DEPT CARDIOL SAN JOSE CA 00000
Titolo Testata:
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
fascicolo: 11, volume: 19, anno: 1996,
parte:, 2
pagine: 2004 - 2008
SICI:
0147-8389(1996)19:11<2004:IAIROT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIUM IN-VITRO; ATRIOVENTRICULAR JUNCTION; CATHETER ABLATION;
Keywords:
ABLATION; MICROWAVE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
6
Recensione:
Indirizzi per estratti:
Citazione:
L.B. Liem et al., "IN-VITRO AND IN-VIVO RESULTS OF TRANSCATHETER MICROWAVE ABLATION USING FORWARD-FIRING TIP ANTENNA DESIGN", PACE, 19(11), 1996, pp. 2004-2008

Abstract

This study was designed to test a microwave (MW) ablation system using approximately 2,450 MHz of energy and a deflectable catheter with fora ard-firing tip antenna, an early clinical prototype system. In vitro three-dimensional thermal mapping of single and double helix antennadesigns was performed. Quantitative measurements of antenna radiationrt ere recorded on tissue phantoms equipped with temperature sensors distributed radially and outwardly. In vivo testing consisted of closed-chest AV junction ablation in three dogs. Thermal mapping showed hemispherical heat distribution from the tip antenna. For the double helix design, this distribution was measured at 8.4-mm diameter with a maximum temperature of 61.62 degrees C. As expected, the single helix design produced less heating with a measured diameter of 6.4 mm and maximum temperature of 55.90 degrees C. The in vivo study produced lesions of geometry and size concordant with these heating patterns. MW ablation produced bundle branch block in one dog and complete AV nodal blockin the remaining two, without transvalvular or other structural damage. The histopathology of the lesions was typical of a thermal burn showing hemorrhage and coagulative necrosis with clearly demarcated borders, We conclude that, using this early clinical prototype system with or deflectable catheter and a forward-firing tip antenna design, MW heating can produce a moderate-size lesion and is safe and effective forcardiac ablation.

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Documento generato il 21/09/20 alle ore 15:58:36