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Titolo:
DECREASED E-CADHERIN EXPRESSION IS ASSOCIATED WITH HEMATOGENOUS RECURRENCE AND POOR-PROGNOSIS IN PATIENTS WITH SQUAMOUS-CELL CARCINOMA OF THE ESOPHAGUS
Autore:
TAMURA S; SHIOZAKI H; MIYATA M; KADOWAKI T; INOUE M; MATSUI S; IWAZAWA T; TAKAYAMA T; TAKEICHI M; MONDEN M;
Indirizzi:
OSAKA UNIV,SCH MED,DEPT SURG 2,2-2 YAMADAOKA SUITA OSAKA 565 JAPAN KYOTO UNIV,FAC SCI,DEPT BIOPHYS KYOTO JAPAN
Titolo Testata:
British Journal of Surgery
fascicolo: 11, volume: 83, anno: 1996,
pagine: 1608 - 1614
SICI:
0007-1323(1996)83:11<1608:DEEIAW>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-CATENIN EXPRESSION; HUMAN ESOPHAGEAL CANCER; LYMPH-NODE METASTASIS; HUMAN GASTRIC-CANCER; IMMUNOHISTOCHEMICAL EVALUATION; ADHESION MOLECULES; PROSTATE-CANCER; DOWN-REGULATION; DEDIFFERENTIATION; INVOLVEMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
S. Tamura et al., "DECREASED E-CADHERIN EXPRESSION IS ASSOCIATED WITH HEMATOGENOUS RECURRENCE AND POOR-PROGNOSIS IN PATIENTS WITH SQUAMOUS-CELL CARCINOMA OF THE ESOPHAGUS", British Journal of Surgery, 83(11), 1996, pp. 1608-1614

Abstract

Reduced expression of E-cadherin is associated with tumour invasiveness and metastasis. To elucidate whether E-cadherin expression correlates with clinical outcome in patients with oesophageal cancer, 62 patients were investigated immunohistochemically using an anti-E-cadherin monoclonal antibody (HECD-1). Eight patients had normal levels of expression in the tumour, 25 had tumours that expressed high levels (50 percent or more tumour cells staining positive for E-cadherin) and 29 had tumours expressing low levels (less than 50 per cent of cells expressing E-cadherin). Patients with normally expressing tumours had a better prognosis at 3 years than those with low-expressing tumours (P < 0.05). Postoperative death was correlated significantly with lymphatic invasion, lymph node metastasis, E-cadherin expression and depth of invasion (P < 0.05). Furthermore, haematogenous recurrence was correlatedwith E-cadherin expression (r(S) = 0.38, P < 0.01) and blood vessel invasion (r(S) = 0.28, P < 0.05). These results suggest that evaluationof E-cadherin immunoreactivity may predict haematogenous recurrence and poor prognosis in patients with oesophageal cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 20:47:19