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Titolo:
LACK OF INTERACTION BETWEEN DEVAZEPIDE AND 8-OH-DPAT-INDUCED HYPERPHAGIA IN THE RAT
Autore:
FRANCIS J; DOURISH CT; COOPER SJ;
Indirizzi:
UNIV SHEFFIELD,NO GEN HOSP,CTR HUMAN NUTR SHEFFIELD S5 7AU S YORKSHIRE ENGLAND CEREBRUS ASCOT SL5 7PN BERKS ENGLAND UNIV DURHAM,DEPT PSYCHOL,SCI LABS DURHAM DH1 3LE ENGLAND
Titolo Testata:
Physiology & behavior
fascicolo: 5, volume: 60, anno: 1996,
pagine: 1337 - 1340
SICI:
0031-9384(1996)60:5<1337:LOIBDA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL RAPHE NEURONS; CHOLECYSTOKININ RECEPTOR; 5-HT1A; SEROTONIN; 5-HYDROXYTRYPTAMINE; INHIBITION; DEPENDS; BRAIN;
Keywords:
CCK-5-HT INTERACTIONS; 8-OH-DPAT; DEVAZEPIDE; FEEDING; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
J. Francis et al., "LACK OF INTERACTION BETWEEN DEVAZEPIDE AND 8-OH-DPAT-INDUCED HYPERPHAGIA IN THE RAT", Physiology & behavior, 60(5), 1996, pp. 1337-1340

Abstract

Recently, a number of studies have provided evidence suggesting that CCK and 5-HT interact in the control of food intake. However, the majority of these studies have relied on the administration of exogenous CCK to investigate potential interactions. The aim of the present studywas to focus on the potential role of endogenous CCK in 5-HT-CCK interactions. Our prediction was that the CCKA antagonist, devazepide, alone would potentiate the hyperphagic effect of the 5-HT1A agonist, 8-OH-DPAT, in free-feeding rats. The results showed that devazepide, at a dose that had no intrinsic effect (1.0 mg/kg), did not enhance the hyperphagic effect of 8-OH-DPAT (100 and 300 mu g/kg). This suggests thatwhen serotonergic inhibitory activity is reduced by 5-HT1A-receptor stimulation, there is no compensatory increase of endogenous CCK activity to excite 5-HT neurons and thereby inhibit food intake. Copyright (C) 1996 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:26:56