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Titolo:
NANC NEURAL CONTROL OF AIRWAY SMOOTH-MUSCLE TONE
Autore:
LINDEN A;
Indirizzi:
GOTHENBURG UNIV,SAHLGRENS HOSP,INST HEART & LUNG DIS,DEPT RESP MED & ALLERGOL S-41345 GOTHENBURG SWEDEN UNIV CALIF SAN FRANCISCO,INST CARDIOVASC RES SAN FRANCISCO CA 94143
Titolo Testata:
General pharmacology
fascicolo: 7, volume: 27, anno: 1996,
pagine: 1109 - 1121
SICI:
0306-3623(1996)27:7<1109:NNCOAS>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE-INTESTINAL-PEPTIDE; GUINEA-PIG AIRWAYS; HISTAMINE-INDUCED BRONCHOCONSTRICTION; NONCHOLINERGIC INHIBITORY SYSTEM; SENSITIVE SENSORY NERVES; NITRIC-OXIDE SYNTHASE; SUBSTANCE-P; NEUROKININ-A; CHOLINERGIC NEUROTRANSMISSION; IMMUNOREACTIVE NERVES;
Keywords:
ADRENERGIC RESPONSES; AIRWAY NERVES; AIRWAY SMOOTH MUSCLE; ASTHMA; BRONCHOCONSTRICTION; CHOLINERGIC RESPONSES; NEUROKININ A; NITRIC OXIDE; PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE; SUBSTANCE P; TACHYKININS; VASOACTIVE INTESTINAL PEPTIDE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
143
Recensione:
Indirizzi per estratti:
Citazione:
A. Linden, "NANC NEURAL CONTROL OF AIRWAY SMOOTH-MUSCLE TONE", General pharmacology, 27(7), 1996, pp. 1109-1121

Abstract

1. This review addresses the functional role of the nonadrenergic, noncholinergic (NANC) neural response in the control of airway smooth muscle tone. 2. Functional data from guinea pig airways in vitro indicate that the Level of basal smooth muscle tone determines the direction and magnitude of the NANC neural response such that it can stabilise tone. 3. The NANC stabilising effect on tone is adjustable through variation in impulse frequency and the NANC stabilising effect is also powerful; it can abolish near maximum differences in tone. 4. Cholinergicactivation increases the level towards which the NANC responses tend to adjust tone. 5. Adrenergic activation reduces the level towards which the NANC responses tend to adjust tone via beta-adrenoceptors. 6. NANC neural activation, with or without simultaneous adrenergic or cholinergic activation, can stabilise tone at low, intermediate or high levels with a high degree of accuracy. 7. Evidence from other investigators on effects of putative NANC neurotransmitters supports the idea offunctional interactions within the NANC system in the airways. 8. It remains to be confirmed whether or not NANC responses pray a stabilising role in the control of airway smooth muscle tone in vivo and in higher mammals. Copyright (C) 1996 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 10:48:05