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Titolo:
ADENOVIRUS DODECAHEDRON, A NEW VECTOR FOR HUMAN GENE-TRANSFER
Autore:
FENDER P; RUIGROK RWH; GOUT E; BUFFET S; CHROBOCZEK J;
Indirizzi:
INST BIOL STRUCT,41 AVE MARTYRS F-38027 GRENOBLE FRANCE INST BIOL STRUCT F-38027 GRENOBLE FRANCE EUROPEAN MOL BIOL LAB,GRENOBLE OUTSTN F-38042 GRENOBLE 9 FRANCE
Titolo Testata:
Nature biotechnology
fascicolo: 1, volume: 15, anno: 1997,
pagine: 52 - 56
SICI:
1087-0156(1997)15:1<52:ADANVF>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PENTON BASE PROTEIN; CELLS; TYPE-2; FIBER; RELEASE; DNA; GENOME;
Keywords:
ADENOVIRUS PENTON; DODECAHEDRON; GENE THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
P. Fender et al., "ADENOVIRUS DODECAHEDRON, A NEW VECTOR FOR HUMAN GENE-TRANSFER", Nature biotechnology, 15(1), 1997, pp. 52-56

Abstract

Recombinant adenovirus is one of most efficient delivery vehicles forgene therapy. However, the initial enthusiasm for the use of recombinant adenovirus for gene therapy has been tempered by strong immune responses that develop to the virus and virus-infected cells. Even thoughrecombinant adenoviruses are replication-defective, they introduce into the recipient cell, together with the gene of interest, viral genetes that might lead to fortuitous recombination if the recipient is infected by wild-type adenovirus, We propose the use of a dodecahedron made of adenovirus pentons or penton bases as an alternative vector for human gene therapy. The penton is a complex of two oligomeric proteins, a penton base and fiber, involved in the cell attachment, internalization, and liberation of virus into the cytoplasm, The dodecahedron retains many of the advantages of adenovirus for gene transfer such as efficiency of entry, efficient release of DNA from endosomes, and wide range of cell and tissue targets. Because it consists of only one or two adenovirus proteins instead of the 11 contained in an adenovirus virion and it does not contain the viral genome, it is potentially a safer alternative to recombinant adenovirus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 13:23:33