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Titolo:
HETERONUCLEAR RIBONUCLEOPROTEINS C1 AND C2, COMPONENTS OF THE SPLICEOSOME, ARE SPECIFIC TARGETS OF INTERLEUKIN 1-BETA-CONVERTING ENZYME-LIKE PROTEASES IN APOPTOSIS
Autore:
WATERHOUSE N; KUMAR S; SONG QH; STRIKE P; SPARROW L; DREYFUSS G; ALNEMRI ES; LITWACK G; LAVIN M; WATTERS D;
Indirizzi:
QUEENSLAND INST MED RES,PO ROYAL BRIBANE HOSP,QUEENSLAND CANC FUND RES UNIT BRISBANE QLD 4029 AUSTRALIA QUEENSLAND INST MED RES,PO ROYAL BRIBANE HOSP,QUEENSLAND CANC FUND RES UNIT BRISBANE QLD 4029 AUSTRALIA UNIV QUEENSLAND,DEPT SURG ST LUCIA QLD 4072 AUSTRALIA HANSON CTR CANC RES ADELAIDE SA 5000 AUSTRALIA CSIRO,DIV BIOMOL ENGN PARKVILLE VIC 3052 AUSTRALIA UNIV PENN,SCH MED,HOWARD HUGHES MED INST,RES LABS,DEPT BIOCHEM & BIOPHYS PHILADELPHIA PA 19104 THOMAS JEFFERSON UNIV,DEPT PHARMACOL PHILADELPHIA PA 19107 THOMAS JEFFERSON UNIV,JEFFERSON CANC INST PHILADELPHIA PA 19107
Titolo Testata:
The Journal of biological chemistry
fascicolo: 46, volume: 271, anno: 1996,
pagine: 29335 - 29341
SICI:
0021-9258(1996)271:46<29335:HRCACC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; HETEROGENEOUS NUCLEAR-RNA; ICE-LIKE PROTEASES; CONVERTING-ENZYME; POLY(ADP-RIBOSE) POLYMERASE; BINDING-PROTEINS; PREMESSENGER RNA; GENE CED-3; IL-1-BETA-CONVERTING ENZYME; MAMMALIAN HOMOLOG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
N. Waterhouse et al., "HETERONUCLEAR RIBONUCLEOPROTEINS C1 AND C2, COMPONENTS OF THE SPLICEOSOME, ARE SPECIFIC TARGETS OF INTERLEUKIN 1-BETA-CONVERTING ENZYME-LIKE PROTEASES IN APOPTOSIS", The Journal of biological chemistry, 271(46), 1996, pp. 29335-29341

Abstract

Apoptosis induced by a variety of agents results in the proteolytic cleavage of a number of cellular substrates by enzymes related to interleukin 1 beta-converting enzyme (ICE). A small number of substrates for these enzymes have been identified to date, including enzymes involved in DNA repair processes: poly(ADP-ribose) polymerase and DNA-dependent protein kinase. We describe here for the first time the specific cleavage of the heteronuclear ribonucleoproteins (hnRNPs) C1 and C2 in apoptotic cells induced to undergo apoptosis by a variety of stimuli, including ionizing radiation, etoposide, and ceramide. No cleavage wasobserved in cells that are resistant to apoptosis induced by ionizingradiation. Protease inhibitor data implicate the involvement of an ICE-like protease in the cleavage of hnRNP C. Using recombinant ICE-likeproteases and purified hnRNP C proteins in. vitro, we show that the Cproteins are cleaved by Mch3 alpha and CPP32 and, to a lesser extent,by Mch2 alpha, but not by ICE, Nedd2, Tx, or the cytotoxic T-cell protease granzyme B. The results described here demonstrate that the hnRNP C proteins, abundant nuclear proteins thought to be involved in RNA splicing, belong to a critical set of protein substrates that are cleaved by ICE-like proteases during apoptosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:27:39