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Titolo:
MAGNETIC-RESONANCE-IMAGING OF FOCAL LIVER-LESIONS - COMPARISON OF THESUPERPARAMAGNETIC IRON-OXIDE RESOVIST VERSUS GADOLINIUM-DTPA IN THE SAME PATIENT
Autore:
VOGL TJ; HAMMERSTINGL R; SCHWARZ W; KUMMEL S; MULLER PK; BALZER T; LAUTEN MJ; BALZER JO; MACK MG; SCHIMPFKY C; SCHREM H; BECHSTEIN WO; NEUHAUS P; FELIX R;
Indirizzi:
HUMBOLDT UNIV BERLIN,UNIV HOSP RUDOLF VIRCHOW,DEPT RADIOL,AUGUSTENBURGER PLATZ 1 D-13353 BERLIN GERMANY SCHERING AG,CLIN DEV DIAG MR & ULTRASOUND CONTRAST MEDIA D-1000 BERLIN GERMANY HUMBOLDT UNIV BERLIN,UNIV HOSP RUDOLF VIRCHOW,DEPT SURG BERLIN GERMANY
Titolo Testata:
Investigative radiology
fascicolo: 11, volume: 31, anno: 1996,
pagine: 696 - 708
SICI:
0020-9996(1996)31:11<696:MOFL-C>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
MR CONTRAST AGENT; FERRITE PARTICLES; NODULAR HYPERPLASIA; CLINICAL-APPLICATION; ENHANCED DETECTION; TUMORS; SPLEEN; PHARMACOKINETICS; DIFFERENTIATION; METASTASES;
Keywords:
MAGNETIC RESONANCE IMAGING; LIVER TUMOR; CONTRAST MEDIA; SUPERPARAMAGNETIC IRON OXIDE; HUMAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
T.J. Vogl et al., "MAGNETIC-RESONANCE-IMAGING OF FOCAL LIVER-LESIONS - COMPARISON OF THESUPERPARAMAGNETIC IRON-OXIDE RESOVIST VERSUS GADOLINIUM-DTPA IN THE SAME PATIENT", Investigative radiology, 31(11), 1996, pp. 696-708

Abstract

RATIONALE AND OBJECTIVES. The authors assess the efficacy of static and dynamic magnetic resonance (MR) imaging using the superparamagneticiron oxide SHU-555A (Resovist(R)) versus standard dose of gadolinium (Gd)-DTPA in patients with focal liver lesions. METHODS. Magnetic resonance imaging was performed in 30 patients suffering from histopathologically verified malignant (n = 22) and benign (n = 8) liver lesions, T2-weighted conventional and fat-suppressed as well as T1-weighted sequences were used before, during, and after fast intravenous administration of Resovist (1 mL/minute) at three doses of 4, 8, and 16 mu mol/kg body weight. One week before the Resovist-enhanced MR imaging study 20 patients underwent Gd-DTPA-enhanced MR imaging. RESULTS. Detection rate was improved for metastatic lesions revealing 36 lesions unenhanced versus 53 focal lesions using Resovist-enhanced MR imaging. Gadolinium-DTPA-enhanced scans showed no additional lesion versus unenhanced and Resovist-enhanced MR imaging. Static and dynamic imaging demonstrated no measurable percentage signal intensity loss (PSIL) using Resovist-enhanced MR imaging versus a percentage enhancement of 79.7% in Gd-DTPA enhanced scans. In the dynamic T2-weighted sequences, hepatocellular carcinoma nodules (n = 4) showed a rapid decrease in signal intensity starting at 44 seconds. Postinfusion of Resovist followed by a low, constant increase in signal intensity. Gadolinium-DTPA enhanced scans showed a percentage enhancement of 73.4 focal nodular hyperplasia (FNH) and hemangioma revealed a strong and early dose-dependent PSIL 44 to 60 seconds postinfusion with a prolonged signal loss for the FNH inthe late study. Statistical evaluation revealed a statistically significant superiority of Resovist-enhanced MR imaging concerning the detection and delineation of focal liver lesions compared with unenhanced and Gd-DTPA enhanced scans (P < 0.05). CONCLUSIONS. The fast infusion of the new superparamagnetic contrast agent Resovist shows advantages for dynamic and static MR imaging of focal liver lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 16:04:08