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Titolo:
STRESS DECREASES LYMPHOCYTE CYTOLYTIC ACTIVITY IN THE YOUNG MONKEY EVEN AFTER BLOCKADE OF STEROID AND OPIATE HORMONE RECEPTORS
Autore:
COE CL; ERICKSON CM;
Indirizzi:
UNIV WISCONSIN,DEPT PSYCHOL,1202 W JOHNSON ST MADISON WI 53706 UNIV WISCONSIN,DEPT ANIM HLTH & BIOMED SCI MADISON WI 53706
Titolo Testata:
Developmental psychobiology
fascicolo: 1, volume: 30, anno: 1997,
pagine: 1 - 10
SICI:
0012-1630(1997)30:1<1:SDLCAI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
KILLER-CELL-ACTIVITY; SOCIAL SEPARATION; IMMUNE-SYSTEM; MATERNAL SEPARATION; SQUIRREL-MONKEYS; INFANT MONKEYS; RESPONSES; DEPRESSION; CORTISOL; INHIBITION;
Keywords:
NATURAL KILLER ACTIVITY; STRESS; SEPARATION; SQUIRREL MONKEY; INFANCY; CORTISOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
C.L. Coe e C.M. Erickson, "STRESS DECREASES LYMPHOCYTE CYTOLYTIC ACTIVITY IN THE YOUNG MONKEY EVEN AFTER BLOCKADE OF STEROID AND OPIATE HORMONE RECEPTORS", Developmental psychobiology, 30(1), 1997, pp. 1-10

Abstract

Lymphocyte cytolytic responses were assessed in 75 infant squirrel monkeys to investigate the influence of psychosocial disturbance on immunity. Four studies evaluated alterations in lytic activity during social separations from the mother lasting for 1-7 days. Lytic responses against target cells were markedly decreased during the first day of separation, and then gradually returned toward baseline levels. Althoughassociated with a general lymphocytopenia in vivo, lower lysis was not mediated specifically by inclusion of fewer Leu11b+ cells in the in vitro assay. Multiple physiological processes probably converge to mediate the decrease in lysis. Treatment of the infant with RU486 to block corticosteroid hormone receptors or with naltrexone to antagonize opiate hormone action did not prevent the decrease in lytic responses from occurring This research demonstrates that psychological disturbancecan significantly impact immunity, but the recovery of normal functioning by I week also reveals the resiliency of the immune system, paralleling the time course of the infant's behavioral adaptation to this challenge. (C) 1997 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:02:52