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Titolo:
FOLLISTATIN CONCENTRATIONS IN MALE SHEEP INCREASE FOLLOWING SHAM CASTRATION CASTRATION OR INJECTION OF INTERLEUKIN-1-BETA/
Autore:
PHILLIPS DJ; HEDGER MP; MCFARLANE JR; KLEIN R; CLARKE IJ; TILBROOK AJ; NASH AD; DEKRETSER DM;
Indirizzi:
MONASH UNIV,INST REPROD & DEV,MONASH MED CTR,LEVEL 3,BLOCK E,CLAYTON RD CLAYTON VIC 3168 AUSTRALIA RMIT,DEPT ANAT & PHYSIOL BUNDOORA VIC 3083 AUSTRALIA MONASH MED CTR,PRINCE HENRYS INST MED RES CLAYTON VIC 3168 AUSTRALIA MONASH UNIV,DEPT PHYSIOL CLAYTON VIC 3168 AUSTRALIA UNIV MELBOURNE,SCH VET SCI,CTR ANIM BIOTECHNOL PARKVILLE VIC 3052 AUSTRALIA
Titolo Testata:
Journal of Endocrinology
fascicolo: 1, volume: 151, anno: 1996,
pagine: 119 - 124
SICI:
0022-0795(1996)151:1<119:FCIMSI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLICLE-STIMULATING-HORMONE; ACTIVIN-BINDING PROTEIN; LUTEINIZING-HORMONE; MONOCLONAL-ANTIBODIES; ESTROUS-CYCLE; RAT OVARY; PITUITARY; FSH; CYTOKINES; INHIBIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
D.J. Phillips et al., "FOLLISTATIN CONCENTRATIONS IN MALE SHEEP INCREASE FOLLOWING SHAM CASTRATION CASTRATION OR INJECTION OF INTERLEUKIN-1-BETA/", Journal of Endocrinology, 151(1), 1996, pp. 119-124

Abstract

Plasma follistatin (FS) concentrations were determined after castration (n=5) or sham castration (n=4) of mature rams. Both treatments resulted in a prolonged increase in FS between 7 and 19 h after surgery, which returned to pretreatment concentrations by 24 h. Tumour necrosis factor-alpha (TNF-alpha), a sensitive marker of an acute-phase response, was undetectable in plasma, indicating that the FS response was notinduced by trauma due to surgery. In a second experiment, injection of castrated rams (n=4) with ovine recombinant interleukin-1 beta, an acute-phase mediator, resulted in a sustained rise in FS concentrationswithin 4 h of injection. Plasma TNF-alpha concentrations increased transiently within 1 h of interleukin-1 beta injection, indicating that an acute-phase response had been initiated. Plasma follicle-stimulating hormone (FSH) concentrations were significantly decreased at 8 and 24 h after interleukin-1 beta injection, strongly suggestive of an inhibitory effect of increased FS concentrations on the secretion of FSH. Injection of castrated rams (n=2) with a control preparation of recombinant interleukin-2 did not induce an acute-phase response, and plasmaFS and FSH concentrations were unaffected. These data show that the testis is not a major source of circulating FS, that the increase in circulating FS following sham castration/castration is not due to an acute-phase response, but that conversely FS concentrations are modulatedby the acute-phase mediator, interleukin-1 beta.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 08:06:34