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Titolo:
EARLY TREATMENT OF A SINGLE GENERALIZED TONIC-CLONIC SEIZURE TO PREVENT RECURRENCE
Autore:
GILAD R; LAMPL Y; GABBAY U; ESHEL Y; SAROVAPINHAS I;
Indirizzi:
EDITH WOLFSON MED CTR,DEPT NEUROL IL-58100 HOLON ISRAEL CHAIM SHEBA MED CTR,GERTI INST STAT IL-52621 TEL HASHOMER ISRAEL TEL AVIV UNIV,SACKLER FAC MED IL-69978 TEL AVIV ISRAEL
Titolo Testata:
Archives of neurology
fascicolo: 11, volume: 53, anno: 1996,
pagine: 1149 - 1152
SICI:
0003-9942(1996)53:11<1149:ETOASG>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
1ST UNPROVOKED SEIZURE; FOLLOW-UP; EPILEPSY; CHILDHOOD; PROGNOSIS; RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
R. Gilad et al., "EARLY TREATMENT OF A SINGLE GENERALIZED TONIC-CLONIC SEIZURE TO PREVENT RECURRENCE", Archives of neurology, 53(11), 1996, pp. 1149-1152

Abstract

Background: The question of whether to start antiepileptic treatment after a single unprovoked seizure remains controversial and has been the subject of much debate in the relevant literature. Objectives: To determine the rate of recurrence of a second attack after a single unprovoked epileptic seizure by using 2 study groups of treated and untreated patients and, thus, to establish a treatment policy for these patients. Patients and Methods: A group of 91 patients with a single generalized tonic-clonic seizure were prospectively studied; 87 of these patients completed the study. The end point of the study was 36 months after the single attack or the occurrence of a subsequent epileptic attack. The patients were randomly divided into 2 groups: 45 patients whoimmediately received anticonvulsive treatment and 42 who remained untreated for the follow-up period. Patients in the treated group were given mono therapy with carbamazepine. The results of recurrences were statistically analyzed by using the Kaplan-Meier method. Results: Results indicated a significantly higher percentage of seizure-free patients in the treated group compared with that in the untreated group (P=.001). The treated men were proved to be less at risk for recurrent seizures compared with treated women (P<.001 vs P=.03, respectively). Conclusion: Treatment after a single unprovoked seizure leads to a significant reduction in the risk of relapse of generalized tonic-clonic epilepsy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:12:38