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Titolo:
INDUCTION OF GLUCOSE-REGULATED PROTEIN (GLUCOSE-REGULATED-PROTEIN-78 BIP AND GLUCOSE-REGULATED-PROTEIN-94) AND HEAT-SHOCK-PROTEIN-70 TRANSCRIPTS IN THE IMMATURE RAT-BRAIN FOLLOWING STATUS EPILEPTICUS/
Autore:
LITTLE E; TOCCO G; BAUDRY M; LEE AS; SCHREIBER SS;
Indirizzi:
UNIV SO CALIF,SCH MED,DEPT NEUROL,1333 SAN PABLO ST,MCH 142 LOS ANGELES CA 90033 UNIV SO CALIF,SCH MED,DEPT NEUROL LOS ANGELES CA 90033 UNIV SO CALIF,SCH MED,DEPT BIOCHEM & MOL BIOL LOS ANGELES CA 90033 UNIV SO CALIF,NEUROSCI PROGRAM LOS ANGELES CA 90089
Titolo Testata:
Neuroscience
fascicolo: 1, volume: 75, anno: 1996,
pagine: 209 - 219
SICI:
0306-4522(1996)75:1<209:IOGP(B>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHAIN-BINDING-PROTEIN; C-FOS EXPRESSION; ENDOPLASMIC-RETICULUM; IMMUNOGLOBULIN-CHAINS; MAMMALIAN-CELLS; DAMAGE SYNDROME; GLYCOPROTEIN-B; STRESS PROTEIN; CALCIUM; GENE;
Keywords:
CHAPERONE; KAINATE; HIPPOCAMPUS; SEIZURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
E. Little et al., "INDUCTION OF GLUCOSE-REGULATED PROTEIN (GLUCOSE-REGULATED-PROTEIN-78 BIP AND GLUCOSE-REGULATED-PROTEIN-94) AND HEAT-SHOCK-PROTEIN-70 TRANSCRIPTS IN THE IMMATURE RAT-BRAIN FOLLOWING STATUS EPILEPTICUS/", Neuroscience, 75(1), 1996, pp. 209-219

Abstract

Prior to 21 days of age, the immature rat brain is relatively resistant to excitotoxicity caused by the glutamate analogue, kainate. As stress-inducible proteins (GRP78, GRP94 and HSP70) have been proposed to possess molecular chaperone activity and protect cells from the deleterious effects of damaged proteins, we examined the pattern of expression of their respective messenger RNAs following systemic kainate at different postnatal ages. In untreated rats between seven and 21 days old, there was a higher basal level of grp78 and grp94 expression compared to hsp70. Unlike hsp70, which was inducible only in 21-day-old rats, kainate-mediated grp94 induction occurred in several regions of the brain as early as postnatal day 7. Grp78 messenger RNA expression was also increased by kainate treatment in 14-day-old rats, and the induction was most pronounced in the kainate-resistant dentate gyrus. With increasing age, longer lasting expression of both grp78 and grp94 messenger RNAs was observed in kainate-vulnerable regions, similar to observations in the adult rat brain. These results demonstrate non-overlapping expression patterns of glucose-regulated proteins and HSP70 in theimmature central nervous system, suggesting that they serve differentfunctions. While hsp70 induction could be a marker for potential cellinjury and death, increased expression of grp78 and grp94 could play a neuroprotective role in the developing rat brain. Copyright (C) 1996IBRO.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 09:52:25