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Titolo:
RANDOMIZED TRIALS IN SINGLE SUBJECTS - THE N OF 1 STUDY
Autore:
COOK DJ;
Indirizzi:
MCMASTER UNIV,FAC HLTH SCI,DEPT CLIN EPIDEMIOL & BIOSTAT,ROOM 2C12,1200 MAIN ST W HAMILTON ON L8N 3Z5 CANADA
Titolo Testata:
Psychopharmacology bulletin
fascicolo: 3, volume: 32, anno: 1996,
pagine: 363 - 367
SICI:
0048-5764(1996)32:3<363:RTISS->2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDIVIDUAL PATIENTS;
Keywords:
N OF 1 STUDY; TRIALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
4
Recensione:
Indirizzi per estratti:
Citazione:
D.J. Cook, "RANDOMIZED TRIALS IN SINGLE SUBJECTS - THE N OF 1 STUDY", Psychopharmacology bulletin, 32(3), 1996, pp. 363-367

Abstract

Large-scale randomized trials are not available for all disorders, and conventional ''trials of therapy'' are susceptible to bias. Randomized controlled trials (RCTs) in individual patients (N of 1 RCTs) may provide a solution, In an N of 1 RCT, a patient receives treatments in pairs (one period of the experimental therapy and one period of eitheran alternative treatment or placebo, in random order), both patient and clinician are kept blind to allocation, and treatment targets are monitored, This type of RCT is useful in chronic, stable conditions in which the proposed treatment has a short half-life. Treatment targets usually include quantitative measurement of symptoms tracked through patient diaries. Pairs of treatment periods are continued until effectiveness is proved or refuted. The N of 1 RCT is potentially of great use in psychopharmacology and in drug development. The practical approach presented here will allow clinicians to conduct their own N of 1 RCTs.

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Documento generato il 27/11/20 alle ore 13:26:40