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Titolo:
EVIDENCE OF IMPROVED MICROVASCULAR PERFUSION WHEN USING ANTEGRADE ANDRETROGRADE CARDIOPLEGIA
Autore:
GATES RN; LEE JG; LAKS H; DRINKWATER DC; RHUDIS E; AHARON AS; CHUNG JY; CHANG PA;
Indirizzi:
HARBOR UCLA MED CTR,DIV CARDIOTHORAC SURG,DEPT SURG,BOX 951741 LOS ANGELES CA 90095 HARBOR UCLA MED CTR,DIV CARDIOTHORAC SURG,DEPT SURG LOS ANGELES CA 90095
Titolo Testata:
The Annals of thoracic surgery
fascicolo: 5, volume: 62, anno: 1996,
pagine: 1388 - 1391
SICI:
0003-4975(1996)62:5<1388:EOIMPW>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY SINUS CARDIOPLEGIA; EFFICACY; OCCLUSION; DELIVERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
R.N. Gates et al., "EVIDENCE OF IMPROVED MICROVASCULAR PERFUSION WHEN USING ANTEGRADE ANDRETROGRADE CARDIOPLEGIA", The Annals of thoracic surgery, 62(5), 1996, pp. 1388-1391

Abstract

Background. The maximum degree of microvascular distribution of cardioplegic solution is considered important to achieve optimum myocardialprotection. This study attempts to demonstrate that the addition of retrograde cardioplegia to antegrade cardioplegia improves overall microvascular perfusion. Methods. Explanted human hearts (n = 6) were treated with cold cardioplegic arrest and bicaval cardiectomy. Blood cardioplegia (37 degrees C) containing colored microspheres (color A for antegrade, color B for retrograde) was simultaneously infused antegrade at a pressure of 80 mm Hg and retrograde at a pressure of 40 mm Hg for2 minutes. The ventricular myocardium was then sampled at three sitesto determine absolute and relative cardioplegic microvascular flow. Results. Of the total microvascular capillary flow, 27% to 32% was found to be the contribution of retrogradely delivered cardioplegia. Conclusions. Despite being delivered simultaneously and at a lower pressure, retrograde cardioplegia contributed substantially to overall microvascular perfusion. This suggests that antegrade cardioplegia alone doesnot perfuse all available myocardial capillaries and that the addition of retrograde cardioplegia enhances overall microvascular distribution and perfusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 02:25:13