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Titolo:
SYNTHESIS AND TURNOVER OF BETA(2)-MICROGLOBULIN IN AD12-TRANSFORMED CELLS DEFECTIVE IN ASSEMBLY AND TRANSPORT OF CLASS-I MAJOR HISTOCOMPATIBILITY COMPLEX-MOLECULES
Autore:
MEYTAL SV; SCHECHTER C; EHRLICH R;
Indirizzi:
TEL AVIV UNIV,GEORGE S WISE FAC LIFE SCI,DEPT CELL RES & IMMUNOL IL-64978 RAMAT AVIV ISRAEL TEL AVIV UNIV,GEORGE S WISE FAC LIFE SCI,DEPT CELL RES & IMMUNOL IL-64978 RAMAT AVIV ISRAEL
Titolo Testata:
The Journal of biological chemistry
fascicolo: 1, volume: 272, anno: 1997,
pagine: 353 - 361
SICI:
0021-9258(1997)272:1<353:SATOBI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-2 MICROGLOBULIN; SURFACE EXPRESSION; T-CELLS; MONOCLONAL-ANTIBODIES; ENDOPLASMIC-RETICULUM; PEPTIDE TRANSPORTER; HUMAN ADENOVIRUSES; HEAVY-CHAIN; FC RECEPTOR; B-CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
S.V. Meytal et al., "SYNTHESIS AND TURNOVER OF BETA(2)-MICROGLOBULIN IN AD12-TRANSFORMED CELLS DEFECTIVE IN ASSEMBLY AND TRANSPORT OF CLASS-I MAJOR HISTOCOMPATIBILITY COMPLEX-MOLECULES", The Journal of biological chemistry, 272(1), 1997, pp. 353-361

Abstract

In primary embryonal fibroblasts from transgenic mice expressing H-2 genes and a miniature swine class I transgene (PD1), transformation with the highly oncogenic Ad12 results in a reduction in peptide transporter and proteasome-associated (LMP2 and LMP7) gene expression, and suppression in transport and cell surface expression of all class I antigens, The selective suppression in transport of H-2 (but not of PD1) molecules in cells reconstituted for the expression of peptide transporter and LMP genes implied that an additional factor(s) is involved in the assembly of class I complexes. Here we show that the beta(2)m, H-2D(b), and H-2K(b) genes are transcribed and translated in Ad12-transformed cells. However, unlike normal and E1Ad5-transformed cells, in which beta(2)m is either secreted unbound or bound to class I heavy chains, in Ad12-transformed cells significant amounts of beta(2)m are retained in the cell bound to the membrane, but free of class I heavy chains. This abnormal turnover of beta(2)m in the Ad12-transformed cells suggests the existence of a novel beta(2)m-binding molecule(s) that sequesters beta(2)m, and this process may provide a mechanism by which transformation with Ad12 may subvert class I complex formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 19:49:18