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Titolo:
INTIMAL HYPERPLASIA IN HUMAN UTERINE ARTERIES ACCOMPANIED BY IMPAIREDSYNERGISM BETWEEN PROSTAGLANDIN I-2 AND NITRIC-OXIDE
Autore:
OBAYASHI S; ASO T; SATO J; HAMASAKI H; AZUMA H;
Indirizzi:
TOKYO MED & DENT UNIV,FAC MED,DEPT OBSTET & GYNAECOL,BUNKYO KU,1-5-45YUSHIMA TOKYO 113 JAPAN TOKYO MED & DENT UNIV,INST MED & DENT ENGN,DEPT MED CHEM,BUNKYO KU TOKYO 113 JAPAN
Titolo Testata:
British Journal of Pharmacology
fascicolo: 5, volume: 119, anno: 1996,
pagine: 1072 - 1078
SICI:
0007-1188(1996)119:5<1072:IHIHUA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; CYCLIC-AMP; DEPENDENT INHIBITION; PROSTACYCLIN ANALOG; ENDOTHELIAL REMOVAL; RECEPTOR ANTAGONIST; PLATELET-FUNCTION; DNA-SYNTHESIS; RELAXATION; BLOOD;
Keywords:
INTIMAL HYPERPLASIA; HUMAN UTERINE ARTERY; CYCLIC AMP; CYCLIC GMP; SYNERGISM BETWEEN PGI(2) AND NO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
S. Obayashi et al., "INTIMAL HYPERPLASIA IN HUMAN UTERINE ARTERIES ACCOMPANIED BY IMPAIREDSYNERGISM BETWEEN PROSTAGLANDIN I-2 AND NITRIC-OXIDE", British Journal of Pharmacology, 119(5), 1996, pp. 1072-1078

Abstract

1 The present experiments were designed to investigate the mechanismscausing intimal hyperplasia in connection with the impaired synergismbetween prostaglandin I-2 (PGI(2)) and nitric oxide (NO) in human uterine arteries (UAs). 2 In order to assess the magnitude of intimal hyperplasia, the intima:media ratio (%) was estimated with the aid of an image analyser. Human UAs were classified into two groups, I and II onthe basis of the ratio and the degree of elastin deposition of histologically normal specimens. The intima:media ratio in group II was determined to be 38.9+/-7.7% (n=6), which was significantly (P<0.01) higher than that in group I (16.5+/-1.5%, n=7). Less deposition of elastin was found in group I than in group II. 3 The relaxation activities of iloprost (IP) as a stable analogue of PGI(2) and sodium nitroprusside (SNP) as a NO donor were not different between the two groups. When the minimum concentrations (C-min) of IP and SNP in producing relaxationwere applied together to the UA strips, these compounds interacted synergistically in group I. The observed relaxation (48.7+/-8.8%, n=7) in this group was significantly (P<0.01) greater than the predicted value of 18.8+/-3.1% (n=7) (the mathematical sum of the relaxations caused by If and SNP alone). By contrast, these agents interacted in an additive manner in group II. The observed relaxation (20.8+/-9.5%, n=6) was not significantly different from the predicted value (18.6+/-2.4%, n=6) in this group. 4 During the relaxation produced by the addition of IP and SNP alone or in combination, the changes in cyclic nucleotides (cyclic AMP and cyclic GMP) contents (pmol mg(-1) protein) were assayed. When If and SNP at C-min were applied together to the UA strips, these compounds interacted synergistically in increasing cyclic nucleotides in group I. The observed net increase in the content was determined to be 1.46+/-0.30 (P<0.05 vs. the predicted value of 0.67+/-0.12) in this group (n=7). By contrast, the observed net increase (0.40+/-0.07, n=6) did not exceed the predicted value (0.65+/-0.07, n=6) in group II. 5 These results suggest that the formation of intimal hyperplasia in group II may be closely related to the impaired synergism betweenPGI(2) and NO in the human UAs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 00:22:21