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Titolo:
CULTURED NEONATAL SCHWANN-CELLS CONTAIN AND SECRETE NEUREGULINS
Autore:
RAABE TD; CLIVE DR; NEUBERGER TJ; WEN D; DEVRIES GH;
Indirizzi:
EDWARD HINES JR VET ADM HOSP,RES SERV 151 HINES IL 60141 LOYOLA UNIV,MED CTR,DEPT CELL BIOL NEUROBIOL & ANAT MAYWOOD IL 60153 EDWARD HINES JR VET ADM HOSP,RES SERV HINES IL 60141 AMGEN INC BOULDER CO 00000 AMGEN INC THOUSAND OAKS CA 91320
Titolo Testata:
Journal of neuroscience research
fascicolo: 2, volume: 46, anno: 1996,
pagine: 263 - 270
SICI:
0360-4012(1996)46:2<263:CNSCAS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEU DIFFERENTIATION FACTOR; PERIPHERAL-NERVE; FACTOR HEREGULIN; GROWTH-FACTORS; PROLIFERATION; EXPRESSION; RECEPTORS; ISOFORMS; ARIA; SURVIVAL;
Keywords:
AUTOCRINE; SCHWANN CELL; NEU DIFFERENTIATION FACTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
T.D. Raabe et al., "CULTURED NEONATAL SCHWANN-CELLS CONTAIN AND SECRETE NEUREGULINS", Journal of neuroscience research, 46(2), 1996, pp. 263-270

Abstract

Neuregulins have become the focus of intense research due to their putative roles in the etiology of certain cancers and to their evolving roles in PNS and CNS development, Evidence has been presented that neuregulins are present in neuronal cells where they act as mediators of neuron-glial signaling, Consistent with this view, we now report that there is a dramatic differential response of Schwann cells to the two major isoforms of neu differentiation factor (NDF alpha and NDF beta),NDF beta is a potent mitogen, whereas NDF alpha is nonmitogenic for Schwann cells, In addition, we report that Schwann cells contain endogenous NDF as well as the mRNA for both isoforms of NDF, Evidence is also presented that several isoforms of NDF are released from cultured Schwann cells. Our data suggest that in addition to functioning as a neuron-glial mediator, endogenous neuregulins may function in an autocrine/paracrine loop or in a juxtacrine- (cell-to-cell) mediated signal between individual Schwann cells or between Schwann cells and neurons. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 19:00:49