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Titolo:
INCREASED MU-OPIOID RECEPTOR-BINDING DETECTED BY PET IN COCAINE-DEPENDENT MEN IS ASSOCIATED WITH COCAINE CRAVING
Autore:
ZUBIETA JK; GORELICK DA; STAUFFER R; RAVERT HT; DANNALS RF; FROST JJ;
Indirizzi:
JOHNS HOPKINS MED INST,DEPT RADIOL,DIV NUCL MED,NELSON B1-130,600 N WOLFE ST BALTIMORE MD 21287 JOHNS HOPKINS MED INST,DEPT RADIOL,DIV NUCL MED BALTIMORE MD 21287 NIDA,INTRAMURAL RES PROGRAM,TREATMENT BRANCH BALTIMORE MD 21224 JOHNS HOPKINS MED INST,DEPT NEUROSCI,DIV NUCL MED BALTIMORE MD 21287
Titolo Testata:
Nature medicine
fascicolo: 11, volume: 2, anno: 1996,
pagine: 1225 - 1229
SICI:
1078-8956(1996)2:11<1225:IMRDBP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; MESSENGER-RNA; EXPOSURE INCREASES; OPIATE RECEPTORS; BRAIN; BUPRENORPHINE; EXPRESSION; METABOLISM; STRIATUM; HUMANS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
J.K. Zubieta et al., "INCREASED MU-OPIOID RECEPTOR-BINDING DETECTED BY PET IN COCAINE-DEPENDENT MEN IS ASSOCIATED WITH COCAINE CRAVING", Nature medicine, 2(11), 1996, pp. 1225-1229

Abstract

The endogenous opioid system has been recently implicated in the reinforcing actions of cocaine and other addictive drugs. In this study weexamined mu opioid receptor binding in ten cocaine-dependent men and seven nonaddicted controls using positron emission tomography and [C-11]carfentanil. Mu opioid binding was increased in several brain regions of the cocaine addicts studied 1-4 days after their last use of cocaine. Binding was positively correlated with the severity of cocaine craving experienced at the time. The upregulation of mu opioid receptor binding persisted after 4 weeks of monitored cocaine abstinence. Thesefindings demonstrate for the first time the involvement of the endogenous opioid system in cocaine dependence and cocaine craving in livinghuman subjects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:28:49