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Titolo:
STRUCTURAL ASPECTS OF SIGNAL-TRANSDUCTION IN B-CELLS
Autore:
VIHINEN M; SMITH CIE;
Indirizzi:
UNIV HELSINKI,DEPT BIOSCI,DIV BIOCHEM,POB 56 FIN-00014 HELSINKI FINLAND KAROLINSKA INST,NOVUM,DEPT BIOSCI,CTR BIOTECHNOL S-14157 HUDDINGE SWEDEN KAROLINSKA INST,DEPT CLIN IMMUNOL S-14186 HUDDINGE SWEDEN
Titolo Testata:
Critical reviews in immunology
fascicolo: 3, volume: 16, anno: 1996,
pagine: 251 - 275
SICI:
1040-8401(1996)16:3<251:SAOSIB>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
X-LINKED AGAMMAGLOBULINEMIA; PLECKSTRIN-HOMOLOGY DOMAIN; PROTEIN-TYROSINE KINASE; TERMINAL SH3 DOMAIN; BETA-GAMMA-SUBUNITS; SEVERE COMBINED IMMUNODEFICIENCY; ADRENERGIC-RECEPTOR KINASE; PHOSPHORYLATED IG-ALPHA; AFFINITY PHOSPHOTYROSYL PEPTIDE; POLYMERASE CHAIN-REACTION;
Keywords:
SIGNAL TRANSDUCTION; BTK; XLA; PROTEIN KINASES; SH2; SH3; PH; TH;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
253
Recensione:
Indirizzi per estratti:
Citazione:
M. Vihinen e C.I.E. Smith, "STRUCTURAL ASPECTS OF SIGNAL-TRANSDUCTION IN B-CELLS", Critical reviews in immunology, 16(3), 1996, pp. 251-275

Abstract

Signal transduction in hematopoietic cells is a highly specific process. The stimulation of B cell receptor following antigen binding triggers, as a first step, phosphorylation of the cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). Src family tyrosine kinases Blk, Fyn, Lck, and Lyn as well as spleen kinase, Syk, are activated to transmit the signal further. In this review the signaling events are discussed in structural terms. The factors related to B cell maturation and their targeted mutations are reviewed. During the last 2 yearsplenty of structural information concerning signaling molecules in B cells has been obtained by using Xray crystallography, NMR spectroscopy, molecular modeling, and mutational analysis. The molecules discussed include Src family kinases, Syk, Grb2 adaptor protein, and Tec family kinases Bmx and Btk. The structure, function, and interactions of these signaling compounds are described in atomic detail.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:52:59