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Titolo:
TEST-RETEST RELIABILITY OF CENTRAL [C-11] RACLOPRIDE BINDING AT HIGH D-2 RECEPTOR OCCUPANCY - A PET STUDY IN HALOPERIDOL-TREATED PATIENTS
Autore:
NYBERG S; FARDE L; HALLDIN C;
Indirizzi:
KAROLINSKA INST,KAROLINSKA HOSP,DEPT CLIN NEUROSCI,PSYCHIAT SECT S-17176 STOCKHOLM SWEDEN
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 3, volume: 67, anno: 1996,
pagine: 163 - 171
SICI:
0925-4927(1996)67:3<163:TROC[R>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; LIVING HUMAN-BRAIN; NAIVE SCHIZOPHRENIC-PATIENTS; C-11 RACLOPRIDE BINDING; DOPAMINE-RECEPTORS; D2-DOPAMINE RECEPTORS; HEAD FIXATION; PHARMACOKINETICS; DECANOATE; DENSITY;
Keywords:
POSITRON EMISSION TOMOGRAPHY; HUMAN; SCHIZOPHRENIA; HALOPERIDOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
S. Nyberg et al., "TEST-RETEST RELIABILITY OF CENTRAL [C-11] RACLOPRIDE BINDING AT HIGH D-2 RECEPTOR OCCUPANCY - A PET STUDY IN HALOPERIDOL-TREATED PATIENTS", PSYCHIATRY RESEARCH-NEUROIMAGING, 67(3), 1996, pp. 163-171

Abstract

Central D-2 dopamine receptor occupancy may be a useful measure to establish clinical guidelines for optimal antipsychotic drug treatment. The use of positron emission tomography (PET) to explore quantitative relationships among D-2 receptor occupancy and clinical effects depends on the reliability of such measurements. The calculation of D-2 receptor occupancy using [C-11]raclopride is routinely based on a ratio-equilibrium analysis, in which the ratio of radioactivity concentration in the striatum to that in the cerebellum is determined. To examine the reliability of such ratios, a test-retest analysis was performed in four schizophrenic patients treated with haloperidol decanoate. PET experiments with [C-11]raclopride were repeated in each subject during the same day. The putamen to cerebellum ratio (P/C ratio) ranged from 1.44 to 1.07 among the four patients, corresponding to a D, receptor occupancy of 62 to 71%. In each subject, the P/C ratios remained highly similar, with quotients 0.98, 1.01, 1.04 and 1.06 between the two experiments. The high test-retest reproducibility of the P/C ratios indicates that measurements of D-2 receptor occupancy with the present methods are highly reliable, and support the further use of PET to optimizethe drug treatment of schizophrenia.

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Documento generato il 19/01/20 alle ore 06:06:55