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Titolo:
A NOSE-BRAIN PATHWAY FOR PSYCHOTROPIC PEPTIDES - EVIDENCE FROM A BRAIN EVOKED-POTENTIAL STUDY WITH CHOLECYSTOKININ
Autore:
PIETROWSKY R; THIEMANN A; KERN W; FEHM HL; BORN J;
Indirizzi:
UNIV LUBECK,KLIN FORSCH GRP,DEPT CLIN NEUROENDOCRINOL,HAUS 23A,RATZEBURGER ALLEE 160 D-23538 LUBECK GERMANY
Titolo Testata:
Psychoneuroendocrinology
fascicolo: 6, volume: 21, anno: 1996,
pagine: 559 - 572
SICI:
0306-4530(1996)21:6<559:ANPFPP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; MOUSE HEPATITIS-VIRUS; BORNA DISEASE VIRUS; ANALOG CERULETIDE; SCHIZOPHRENIC-PATIENTS; OLFACTORY PATHWAYS; VOMERONASAL SYSTEM; PREFRONTAL CORTEX; AREA POSTREMA; BINDING-SITES;
Keywords:
BLOOD-BRAIN-BARRIER; NOSE-BRAIN-BARRIER; CHOLECYSTOKININ; CCK; AUDITORY EVOKED POTENTIAL; P3; HUMAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
R. Pietrowsky et al., "A NOSE-BRAIN PATHWAY FOR PSYCHOTROPIC PEPTIDES - EVIDENCE FROM A BRAIN EVOKED-POTENTIAL STUDY WITH CHOLECYSTOKININ", Psychoneuroendocrinology, 21(6), 1996, pp. 559-572

Abstract

The access of substances to the brain is of particular relevance for the etiology and treatment of psychiatric and neurologic diseases. This study provides functional evidence for a direct access of peptides to the human brain after intranasal administration. Effects were compared of intranasal (IN, 10 mu g) and intravenous (IV, 0.25 and 2.5 mu g)administered cholecystokinin-8 (CCK) on the auditory event related potential (AERP) in 20 healthy subjects. Also, plasma concentration of cortisol and ACTH were monitored. The study was designed as a placebo-controlled, double-blind within-subject cross-over comparison. AERPs were recorded while the subject performed on an attention task (oddball task). Plasma CCK concentrations after IN administration of CCK were comparable to those after IV administration of 0.25 mu g CCK, but were substantially lower than those after 2.5 mu g CCK. The P3 complex of the AERP was markedly increased following the IN administration of CCK (p < .01) compared to placebo and to the IV administration of 0.25 mu g. This pattern was more obvious in women than men. Increases in plasma ACTH concentrations after CCK reached significance selectively following the IN mode of administration (p < .01). Copyright (C) 1996 Elsevier Science Ltd

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Documento generato il 25/01/20 alle ore 06:55:09