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Titolo:
DEVELOPMENTAL DIFFERENCES DETERMINE LARVAL SUSCEPTIBILITY TO NITRIC OXIDE-MEDIATED KILLING IN A MURINE MODEL OF VACCINATION AGAINST SCHISTOSOMA-MANSONI
Autore:
AHMED SF; OSWALD IP; CASPAR P; HIENY S; KEEFER L; SHER A; JAMES SL;
Indirizzi:
NIAID,PARASITOL & INT PROGRAMS BRANCH,NIH,IMMUNOBIOL SECT,LAB PARASITDIS,SOLAR BLDG,ROOM 3A-10 BETHESDA MD 20892 NIAID,PARASITOL & INT PROGRAMS BRANCH,NIH,IMMUNOBIOL SECT,LAB PARASITDIS BETHESDA MD 20892 NCI,CHEM SECT,COMPARAT CARCINOGENESIS LAB FREDERICK MD 21702
Titolo Testata:
Infection and immunity
fascicolo: 1, volume: 65, anno: 1997,
pagine: 219 - 226
SICI:
0019-9567(1997)65:1<219:DDDLST>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUNG-STAGE; PROTECTIVE IMMUNITY; GLUCOSE-METABOLISM; CYTO-TOXICITY; IN-VITRO; MICE; MACROPHAGES; HELMINTHS; MIGRATION; PHASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
S.F. Ahmed et al., "DEVELOPMENTAL DIFFERENCES DETERMINE LARVAL SUSCEPTIBILITY TO NITRIC OXIDE-MEDIATED KILLING IN A MURINE MODEL OF VACCINATION AGAINST SCHISTOSOMA-MANSONI", Infection and immunity, 65(1), 1997, pp. 219-226

Abstract

A persistent paradox in our understanding of protective immunity against Schistosoma mansoni infection in animals vaccinated with attenuated parasites has been that attrition of challenge parasites occurs during migration through the lungs in vivo, although parasites recovered from the lungs appear to be relatively resistant to cytotoxic effector mechanisms in vitro. We have compared the susceptibilities of different stages of larvae to killing by nitric oxide (NO), which was previously shown to be involved in the larvicidal function of cytokine-activated cytotoxic effector cells, Lung-stage larvae obtained 1 week after infection were not killed in vitro by NO generated either by a chemicalNO donor or by activated cells, In contrast, parasites obtained from the portal system of control mice or from the lungs of vaccinated mice2.5 weeks following challenge infection were killed by NO. As previously shown for mammalian cell targets, the effects of NO in susceptiblelarval stages may involve enzymes required for aerobic energy metabolism, since similar cytotoxicity was demonstrated by chemical inhibitors of the citric acid cycle or mitochondrial respiration, Taken together with previous observations of enhanced Th1 activity and expression of NO synthase in the lungs of vaccinated mice at 2.5 weeks after challenge infection, these observations elucidate the immune mechanism of vaccine-induced resistance to S, mansoni infection, Moreover, they suggest that conversion to a less metabolically active state may allow pathogens to escape the effects of the important effector molecule NO.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:57:27