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Titolo:
IN-VIVO EFFICACY OF ORAL AND INTRALESIONAL ADMINISTRATION OF 2-SUBSTITUTED QUINOLINES IN EXPERIMENTAL TREATMENT OF NEW-WORLD CUTANEOUS LEISHMANIASIS CAUSED BY LEISHMANIA-AMAZONENSIS
Autore:
FOURNET A; FERREIRA ME; DEARIAS AR; DEORTIZ ST; FUENTES S; NAKAYAMA H; SCHININI A; HOCQUEMILLER R;
Indirizzi:
ORSTOM,INST FRANCAIS RECH SCI DEV COOPERAT,CASILLA CORREO 97 ASUNCIONPARAGUAY INST INVEST CIENCIAS SALUD,DEPT TROP MED ASUNCION PARAGUAY FAC PHARM CHATENAY MALABRY,CNRS,LAB PHARMACOGNOSIE F-92296 CHATENAY MALABRY FRANCE
Titolo Testata:
Antimicrobial agents and chemotherapy
fascicolo: 11, volume: 40, anno: 1996,
pagine: 2447 - 2451
SICI:
0066-4804(1996)40:11<2447:IEOOAI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; VISCERAL LEISHMANIASIS; GALIPEA-LONGIFLORA; ALKALOIDS; MICE; SUSCEPTIBILITY; CYTOKINES; PATIENT; BOLIVIA; PLANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
A. Fournet et al., "IN-VIVO EFFICACY OF ORAL AND INTRALESIONAL ADMINISTRATION OF 2-SUBSTITUTED QUINOLINES IN EXPERIMENTAL TREATMENT OF NEW-WORLD CUTANEOUS LEISHMANIASIS CAUSED BY LEISHMANIA-AMAZONENSIS", Antimicrobial agents and chemotherapy, 40(11), 1996, pp. 2447-2451

Abstract

The antileishmanial efficacies of 2-n-propylquinoline, chimanines B and D, 2-n-pentylquinoline, 2-phenylquinoline, 2-(3,1-methylenedioxyphenylethyl)quinoline, and two total alkaloidal extracts of Galipea longiflora were evaluated in BALB/c mice infected with Leishmania amazonensis or Leishmania venezuelensis. Animals were treated for 4 to 6 weeks postinfection with a quinoline by the oral route at 50 mg/kg of body weight twice a daily for 15 days or by five intralesional injections atintervals of 4 days with a quinoline at 50 mg/kg of body weight. The reference drug, N-methylglucamine antimonate (Glucantime), was administered by subcutaneous or intralesional injection (regimens of 14, 28, or 56 mg of pentavalent antimony [Sb-v] per kg of body weight daily), Twice-daily oral treatment with chimanine B at 50 mg/kg resulted in a decrease in lesion weight by 70% (P < 0.001) and a decrease in the parasite loads by 95% (P < 0.001), Five injections of chimanine B at intervals of 4 days reduced the lesion weight by 74% and the parasite loads in the lesion by 90% compared with the values for the group of untreated mice, Subcutaneous administration of N-methylglucamine antimonateat 28 mg of Sb-v kg per day for 15 days reduced the parasite burden by 95% (P < 0.001), and five intralesional injections at the same concentration reduced the parasite burden by 96% (P < 0.001), Other 2-substituted quinolines, 2-n-propylquinoline administered by the oral and intralesional routes, 2-phenylquinoline administered by the oral route, 2-n-pentylquinoline administered by intralesional injection, and two total alkaloidal extracts of C. longiflora administered by the oral route, had intermediate effects, These findings suggest that chimanine B may be chosen as a lead molecule in the development of oral therapy against leishmaniasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:28:18