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Titolo:
ACETYL CHOLINESTERASE IS EXPRESSED IN THE FOLLICULAR DENDRITIC CELLS OF GERMINAL-CENTERS - DIFFERENCES BETWEEN NORMAL AND NEOPLASTIC FOLLICLES
Autore:
LAMPERT IA; VANNOORDEN S;
Indirizzi:
ROYAL POSTGRAD MED SCH,DEPT HISTOPATHOL,DUCANE RD LONDON W12 0NN ENGLAND
Titolo Testata:
Journal of pathology
fascicolo: 2, volume: 180, anno: 1996,
pagine: 169 - 174
SICI:
0022-3417(1996)180:2<169:ACIEIT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETICULUM CELLS; GROWTH; ACETYLCHOLINESTERASE; INHIBITION; TISSUE;
Keywords:
GERMINAL CENTER; FOLLICULAR DENDRITIC CELL; ACETYL CHOLINESTERASE; FOLLICLE CENTER LYMPHOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
I.A. Lampert e S. Vannoorden, "ACETYL CHOLINESTERASE IS EXPRESSED IN THE FOLLICULAR DENDRITIC CELLS OF GERMINAL-CENTERS - DIFFERENCES BETWEEN NORMAL AND NEOPLASTIC FOLLICLES", Journal of pathology, 180(2), 1996, pp. 169-174

Abstract

Acetyl cholinesterase (AcChE) was demonstrated by histochemistry in the follicular dendritic cells (FDCs) of the germinal centres of lymph nodes, tonsils, and bowel lymphoid tissue. Its presence in the FDCs was confirmed by double immunostaining for CD21 or DRC-1. AcChE-positiveFDCs are concentrated in the inner portion of the light zone of the germinal centre, being absent from the dark zone. In the lymphoid tissue surrounding the germinal centres are AcChE-positive blood vessels; double staining shows that the AcChE is present in the pericytes surrounding the endothelium of the blood vessels. In contrast to the reactive follicle, the AcChE reactivity in FDCs of follicle centre lymphoma is absent or minimally expressed, although the dense FDC mesh is well stained with CD21 or DRC-1. This suggests that the AcChE is not constitutively expressed in FDCs but that its expression is influenced by thestate and activity of the lymphoid cells in the germinal centre. The reduced level of AcChE staining can be profitably employed in the diagnosis of follicle centre lymphoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 11:18:06