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Titolo:
MACROPHAGE-COLONY-STIMULATING FACTOR (M-CSF) ENHANCES PROTEINURIA ANDRECRUITMENT OF MACROPHAGES INTO THE GLOMERULUS IN EXPERIMENTAL MURINENEPHRITIS
Autore:
UTSUNOMIYA Y; OMURA K; YOKOO T; IMASAWA T; KAWAMURA T; ABE A; HIRANO K; MITARAI T; MARUYAMA N; SAKAI O;
Indirizzi:
JIKEI UNIV,SCH MED,DEPT INTERNAL MED 2,MINATO KU,3-19-18 NISHI SHINBASHI TOKYO 105 JAPAN JIKEI UNIV,SCH MED,DEPT INTERNAL MED TOKYO JAPAN TOKYO METROPOLITAN INST GERONTOL,DEPT MOL PATHOL TOKYO JAPAN
Titolo Testata:
Clinical and experimental immunology
fascicolo: 2, volume: 106, anno: 1996,
pagine: 286 - 296
SICI:
0009-9104(1996)106:2<286:MF(EPA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; GROWTH-FACTOR; LUPUS NEPHRITIS; FACTOR-I; EXPRESSION; INDUCTION; MICE; GLOMERULONEPHRITIS; ADHESION; INJURY;
Keywords:
MACROPHAGE-COLONY STIMULATING FACTOR; NEPHRITIS; GLOMERULAR INJURY; MACROPHAGES; INTERCELLULAR ADHESION MOLECULE-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
Y. Utsunomiya et al., "MACROPHAGE-COLONY-STIMULATING FACTOR (M-CSF) ENHANCES PROTEINURIA ANDRECRUITMENT OF MACROPHAGES INTO THE GLOMERULUS IN EXPERIMENTAL MURINENEPHRITIS", Clinical and experimental immunology, 106(2), 1996, pp. 286-296

Abstract

In this study, we examined the effects of macrophage-colony stimulating factor (M-CSF) on glomerular macrophages in lipopolysaccharide (LPS)-induced murine nephritis. Mice injected intraperitoneally with either M-CSF plus LPS, LPS alone, M-CSF alone or saline every day for 8 days were examined for the degree of urine albumin excretion and lymphocyte-function associated antigen-1-positive (LFA-1(+)) cells in peripheral blood as well as renal pathology. From our results, LPS or M-CSF combined with LPS emphasized the degree of proteinuria, glomerular deposition of immunoglobulins and mesangial proliferation, associated with accumulation of macrophages in the glomeruli. However, in immunohistological examination of kidneys from these nephritic mice, neither intercellular adhesion molecule-1 (ICAM-1), which may play an important role in the recruitment of macrophages into glomeruli, M-CSF receptor northe number of LFA-1(+) cells in peripheral blood was enhanced by M-CSF. On the other hand, M-CSF alone induced neither proteinuria nor any pathological changes and did not increase the number of glomerular Mac-1(+) cells above that in saline-treated controls. These results indicate that M-CSF does not directly cause glomerulonephritis but might participate in accelerating the glomerular inflammatory process by stimulating a potent chemoattractant to recruit monocytes-macrophages into the glomeruli.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 16:56:38