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Titolo:
NEURONS IN THE RAT-BRAIN AND SPINAL-CORD LABELED AFTER PSEUDORABIES VIRUS INJECTED INTO THE EXTERNAL URETHRAL SPHINCTER
Autore:
NADELHAFT I; VERA PL;
Indirizzi:
VET ADM MED CTR,RES & DEV SERV BAY PINES FL 33504 GEORGE WASHINGTON UNIV,DEPT NEUROSURG WASHINGTON DC 20037
Titolo Testata:
Journal of comparative neurology
fascicolo: 3, volume: 375, anno: 1996,
pagine: 502 - 517
SICI:
0021-9967(1996)375:3<502:NITRAS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; PONTINE MICTURITION CENTER; CORTICOTROPIN-RELEASING FACTOR; EDINGER-WESTPHAL NUCLEUS; URINARY-BLADDER; BARRINGTONS NUCLEUS; DIRECT PROJECTIONS; PELVIC NERVE; DESCENDING PROJECTIONS; PREGANGLIONIC NEURONS;
Keywords:
URINATION; NEUROANATOMY; INTERNEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
77
Recensione:
Indirizzi per estratti:
Citazione:
I. Nadelhaft e P.L. Vera, "NEURONS IN THE RAT-BRAIN AND SPINAL-CORD LABELED AFTER PSEUDORABIES VIRUS INJECTED INTO THE EXTERNAL URETHRAL SPHINCTER", Journal of comparative neurology, 375(3), 1996, pp. 502-517

Abstract

Male Sprague-Dawley rats, with their pelvic and hypogastric nerves transected, were infected with pseudorabies virus (PRV) injected into the external urethral sphincter. Animals were sacrificed at 2, 2.5, 3, and 4 days postinfection. Spinal cord and brain tissue were sectioned and processed by immunohistochemical techniques pith antisera against PRV and choline acetyl transferase (CAT). At 2 days postinfection, virus-labeled neurons were found in the ventrolateral divisions of Onuf's nucleus and in the dorsal gray commissure (DGC). At progressively later incubation times, labeled neurons were found in the intermediolateral regions, the superficial layer of the dorsal horn, and the brainstem, in particular, the pontine micturition center. PRV/CAT-positive neurons were only found in Onuf's nucleus. Preganglionic neurons in the L6-S1 intermediolateral regions were CAT positive but PRV negative, thussuggesting that they are interneurons, not sacral parasympathetic preganglionic neurons. After 4 days, virus had spread to neurons in the paraventricular, preoptic, and even cortical regions. The distribution of these PRV-labeled brain neurons strongly resembled that obtained after the injection of PRV into the urinary bladder (Nadelhaft et al. [1992] Neurosci. Lett. 143:271-274). In both cases, neurons were labeledin the DGC in the spinal cord. The data therefore suggest that neurons in the DGC may be involved in the integrated control of the bladder and the external urethral sphincter. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:31:15