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Titolo:
TUMOR-NECROSIS-FACTOR RECEPTOR-1 SIGNALING IS REQUIRED FOR DIFFERENTIATION OF FOLLICULAR DENDRITIC CELLS, GERMINAL CENTER FORMATION, AND FULL ANTIBODY-RESPONSES
Autore:
LEHIR M; BLUETHMANN H; KOSCOVILBOIS MH; MULLER M; DIPADOVA F; MOORE M; RYFFEL B; EUGSTER HP;
Indirizzi:
ETH ZURICH,INST TOXICOL,SCHORENSTR 16 CH-8603 SCHWERZENBACH SWITZERLAND F HOFFMANN LA ROCHE & CO LTD,PHARMACEUT RES GENE TECHNOL CH-4002 BASEL SWITZERLAND SANDOZ LTD,PRECLIN RES CH-4002 BASEL SWITZERLAND UNIV BASEL,INST PATHOL BASEL SWITZERLAND GLAXO INST MOL BIOL SA PLAN LES OUATES SWITZERLAND GENENTECH INC SAN FRANCISCO CA 94080
Titolo Testata:
Journal of inflammation
fascicolo: 1-2, volume: 47, anno: 1996,
pagine: 76 - 80
SICI:
1078-7852(1996)47:1-2<76:TRSIRF>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOLOGICAL MEMORY; MICE; LYMPHOTOXIN; DEFICIENT; ANTIGEN;
Keywords:
TUMOR NECROSIS FACTOR; FOLLICULAR DENDRITIC CELLS; GERMINAL CENTER FORMATION; LYMPHOTOXIN ALPHA; ANTIBODY RESPONSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
M. Lehir et al., "TUMOR-NECROSIS-FACTOR RECEPTOR-1 SIGNALING IS REQUIRED FOR DIFFERENTIATION OF FOLLICULAR DENDRITIC CELLS, GERMINAL CENTER FORMATION, AND FULL ANTIBODY-RESPONSES", Journal of inflammation, 47(1-2), 1996, pp. 76-80

Abstract

Using mice double deficient for tumor necrosis factor ann lymphotoxinalpha (TNF/LT alpha(-/-)) we have demonstrated that TNF and/or LT alpha are important for morphogenesis of secondary lymphoid organs and for T-cell-dependent antibody responses. In the present study we attempted to identify the receptors involved in those functions of TNF and LTalpha. Spleen morphology and antibody responses were investigated in wild-type TNFR1(-/-), TNFR2(-/-), and TNF/LT alpha(-/-) mice immunizedwith SRBC. TNF/LT alpha(-/-) mice, which have a complete disruption of the TNF/LT alpha signaling system including the lymphotoxin beta (LTbeta) receptor pathway, displayed an abnormal splenic microarchitecture and isotype switch did not take place. TNFR1(-/-) and TNFR2(-/-) mice displayed a normal splenic morphology and mounted an IgM and IgG antibody response to SRBC However, the IgG production in TNFR1(-/-) micewas abnormal, with titers leveling off after 6 days following primaryimmunization, and with a minimal response to a second antigen challenge. Immunofluorescence analysis of spleen sections revealed in this strain a lack of follicular dendritic cell (FDC) network and of germinalcenters. In conclusion, while normal splenic microarchitecture and isotype switch might require the LTP receptor differentiation of the FDCnetwork, development of germinal centers, a sustained IgG response, and probably the development of memory cells depend on signaling via TNFR1. (C) 1996 Wiley-Liss, Inc.

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Documento generato il 27/01/21 alle ore 02:09:02