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Titolo:
EXPERIMENTAL BASIS FOR REALISTIC LARGE-SCALE COMPUTER-SIMULATION OF THE ENTERIC NERVOUS-SYSTEM
Autore:
FURNESS JB; BORNSTEIN JC; KUNZE WAA; BERTRAND PP; KELLY H; THOMAS EA;
Indirizzi:
UNIV MELBOURNE,DEPT ANAT & CELL BIOL PARKVILLE VIC 3052 AUSTRALIA UNIV MELBOURNE,DEPT PHYSIOL PARKVILLE VIC 3052 AUSTRALIA
Titolo Testata:
Clinical and experimental pharmacology and physiology
fascicolo: 9, volume: 23, anno: 1996,
pagine: 786 - 792
SICI:
0305-1870(1996)23:9<786:EBFRLC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PIG SMALL-INTESTINE; ACTIVITY-INDUCED EXPRESSION; GUINEA-PIG; MYENTERIC NEURONS; MECHANICAL STIMULATION; FOS IMMUNOREACTIVITY; SUBMUCOSAL PLEXUS; SENSORY NEURONS; CIRCULAR MUSCLE; PROJECTIONS;
Keywords:
COMPUTATIONAL NEUROSCIENCE; COMPUTER SIMULATION; ENTERIC NERVOUS SYSTEM; NEUROCHEMISTRY; NEUROPHYSIOLOGY; PERISTALTIC REFLEXES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
J.B. Furness et al., "EXPERIMENTAL BASIS FOR REALISTIC LARGE-SCALE COMPUTER-SIMULATION OF THE ENTERIC NERVOUS-SYSTEM", Clinical and experimental pharmacology and physiology, 23(9), 1996, pp. 786-792

Abstract

1. The enteric nervous system is perhaps the most accessible part of the mammalian nervous system in which it is feasible to attempt large scale computer simulation that is based closely on experimentally determined data. Here we summarize the data obtained for simulation of motility reflexes in the guinea-pig small intestine. 2. The chemistry, morphology and connectivity of each type of neuron involved in intrinsicreflexes have been investigated and most classes of neurons are physiologically well characterized. This includes primary sensory neurons, ascending and descending interneurons and motor neurons to circular and longitudinal muscle. 3. The responses of primary sensory neurons andthe physiology of synaptic transmission from sensory neurons to interneurons and motor neurons, from interneurons to interneurons and from interneurons to motor neurons have been recorded during reflexes and in some cases the pharmacology of transmission has also been investigated. 4. Computer simulation, in which the activities of up to 30 000 neurons are modelled, produces patterns of activity that closely mimic those recorded in physiological experiments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:31:54