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Titolo:
PROLACTIN MONITORING OF HALOPERIDOL AND PIMOZIDE TREATMENT IN CHILDREN WITH TOURETTES-SYNDROME
Autore:
SALLEE FR; DOUGHERTY D; SETHURAMAN G; VRINDAVANAM N;
Indirizzi:
MED UNIV S CAROLINA,171 ASHLEY AVE CHARLESTON SC 29425
Titolo Testata:
Biological psychiatry
fascicolo: 10, volume: 40, anno: 1996,
pagine: 1044 - 1050
SICI:
0006-3223(1996)40:10<1044:PMOHAP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE SCHIZOPHRENIA; TARDIVE-DYSKINESIA; CLINICAL-RESPONSE; PLASMA PROLACTIN; SERUM PROLACTIN; DISORDER;
Keywords:
PROLACTIN; HALOPERIDOL; PIMOZIDE; TOURETTES SYNDROME; EXTRAPYRAMIDAL SYMPTOMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
F.R. Sallee et al., "PROLACTIN MONITORING OF HALOPERIDOL AND PIMOZIDE TREATMENT IN CHILDREN WITH TOURETTES-SYNDROME", Biological psychiatry, 40(10), 1996, pp. 1044-1050

Abstract

Neuroleptic therapy of children and adolescents,with Tourette's syndrome (GTS) is associated with unpredictable outcome and adverse drug responses (i.e., extrapyramidal symptoms). Assessing the potential outcomes in GTS from a physiologic marker such as plasma prolactin concentration is important in limiting exposure and optimizing therapy. In a double-blind, placebo-controlled, double crossover comparison of pimozide and haloperidol therapy, prolactin, tic severity, and extrapyramidal symptoms were assessed at a 6-week end point. Twenty-six GTS patients (10.5 +/- 2.6 years), experienced clinical response rates of 69% on 3.4 +/- 1.6 mg pimozide and 65% on 3.5 +/- 2.2 mg/day haloperidol, Pimozide responders demonstrate elevated prolactin (26.1 +/- 11.8 ng/mL) versus pimozide nonresponders (10.5 +/- 3.8 ng/mL) (p =.05) and haloperidol treated patients (p =.05). Prolactin may be a marker for tic response to pimozide, and conversely, a potential marker for haloperidol-related incidence of extrapyramidal symptoms during halaperidol therapy. (C) 1996 Society of Biological Psychiatry

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:46:55