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Titolo:
REMODELING OF NUCLEAR ARCHITECTURE DURING THE CELL-CYCLE IN DROSOPHILA EMBRYOS
Autore:
JOHANSEN KM; JOHANSEN J; BAEK KH; JIN Y;
Indirizzi:
IOWA STATE UNIV,DEPT ZOOL & GENET,3154 MOL BIOL BLDG AMES IA 50011
Titolo Testata:
Journal of cellular biochemistry
fascicolo: 3, volume: 63, anno: 1996,
pagine: 268 - 279
SICI:
0730-2312(1996)63:3<268:RONADT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MITOTIC APPARATUS PROTEIN; MICROTUBULE FLUX; NUMA PROTEIN; MONOCLONAL-ANTIBODIES; CHROMOSOME MOVEMENT; MITOSIS; MATRIX; SPINDLE; NUCLEOSKELETON; ORGANIZATION;
Keywords:
NUCLEAR MATRIX; MITOSIS; DROSOPHILA EMBRYO; MONOCLONAL ANTIBODY; SPINDLE FORMATION; NUCLEUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
K.M. Johansen et al., "REMODELING OF NUCLEAR ARCHITECTURE DURING THE CELL-CYCLE IN DROSOPHILA EMBRYOS", Journal of cellular biochemistry, 63(3), 1996, pp. 268-279

Abstract

Little is known about what determines the nuclear matrix or how its reorganization is regulated during mitosis. In this study we report on a monoclonal antibody, mAb2A, which identifies a novel nuclear structure in Drosophila embryos which forms a diffuse meshwork at interphase but which undergoes a striking reorganization into a spindle-like structure during pro- and metaphase. Double labelings with alpha-tubulin and mAb2A antibodies demonstrate that the microtubules of the mitotic apparatus co-localize with this mAb2A labeled structure during metaphase, suggesting it may serve a role in microtubule spindle assembly and/or function during nuclear division. That the mAb2A-labeled nuclear structure is essential for cell division and/or maintenance of nuclear integrity was directly demonstrated by microinjection of mAb2A into early syncytial embryos which resulted in a disintegration of nuclear morphology and perturbation of mitosis. (C) 1996 Wiley-Liss, Inc.

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Documento generato il 02/10/20 alle ore 01:44:22