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Titolo:
BIOCHEMICAL-ANALYSIS OF MUSCLE BIOPSY IN OVERNIGHT FASTING PATIENTS WITH SEVERE CHRONIC HEART-FAILURE
Autore:
OPASICH C; AQUILANI R; DOSSENA M; FOPPA P; CATAPANO M; PAGANI S; PASINI E; FERRARI R; TAVAZZI L; PASTORIS O;
Indirizzi:
UNIV PAVIA,FAC SCI MM FF NN,IST FARMACOL,PIAZZA BOTTA 11 I-27100 PAVIA ITALY UNIV PAVIA,FAC SCI MM FF NN,IST FARMACOL I-27100 PAVIA ITALY MED CTR MONTESCANO PAVIA ITALY FDN CLIN LAVORO,INST CARE & RES,CARDIOVASC PHYSIOPATHOL LAB PAVIA ITALY
Titolo Testata:
European heart journal
fascicolo: 11, volume: 17, anno: 1996,
pagine: 1686 - 1693
SICI:
0195-668X(1996)17:11<1686:BOMBIO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR MAGNETIC-RESONANCE; TUMOR-NECROSIS-FACTOR; SKELETAL-MUSCLE; EXERCISE INTOLERANCE; METABOLISM; ABNORMALITIES; RECEPTORS; CALCIUM; BLOOD; FLOW;
Keywords:
HEART FAILURE; MUSCLE METABOLISM; NUTRITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
C. Opasich et al., "BIOCHEMICAL-ANALYSIS OF MUSCLE BIOPSY IN OVERNIGHT FASTING PATIENTS WITH SEVERE CHRONIC HEART-FAILURE", European heart journal, 17(11), 1996, pp. 1686-1693

Abstract

To better characterize the role of skeletal muscle in chronic heart failure we studied energetic charge, metabolites and enzyme activity inthe energy production pathway. We selected 15 males with severe chronic heart failure (NYHA class III, stable clinical conditions and in normal nutritional status) and seven controls. Controls and patients were submitted to biopsy of the vastus lateralis muscle in resting and fasting conditions. Hormone profiles were also evaluated. Our results showed near normal ATP, ADP and AMP concentrations, but there were substantially more reductions in glycogen (46 +/- 5 vs 77 +/- 6 mu moles glycosidic units.g(-1) fresh tissue) and creatine phosphate (5 +/- 1 vs 13 +/- 1 mu moles.g(-1) fresh tissue) in patients than in controls. Wealso found a reduction in glycolytic activity (pyruvate kinase 1009 +/- 79 vs 1625 +/- 26 nmoles.min(-1).mg protein(-1)), despite normal tricarboxylic acid cycle velocity, an increase in alanine aminotransferase (964 +/- 79 vs 425 +/- 34 nmoles.min(-1).mg protein(-1)) and in aspartate aminotransferase (515 +/- 44 vs 291 +/- 56 nmoles.min(-1).mg protein(-1)). An increase was also observed in total NADH cytochrome c reductase (128 +/- 14 vs 68 +/- 5 nmoles.min(-1).mg protein(-1)), whilecytochrome oxidase activity was normal. The cortisol/insulin ratio was slightly elevated (77 +/- 4 vs 32 +/- 12). In conclusion. normonutritive patients with severe heart failure show an imbalance in the energy production/utilization ratio. The impairment is probably due both toa decrease in production and an increase in consumption of energy owing to greater cellular workload and/or a hypercatabolic state.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 09:01:18