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Titolo:
SKELETAL-MUSCLE CHANGES IN PATIENTS WITH CHRONIC HEART-FAILURE BEFOREAND AFTER TREATMENT WITH ENALAPRIL
Autore:
SCHAUFELBERGER M; ANDERSSON G; ERIKSSON BO; GRIMBY G; HELD P; SWEDBERG K;
Indirizzi:
GOTHENBURG UNIV,OSTRA HOSP,DEPT MED S-41685 GOTHENBURG SWEDEN GOTHENBURG UNIV,OSTRA HOSP,DEPT PEDIAT S-41685 GOTHENBURG SWEDEN UNIV GOTHENBURG,SAHLGRENSKA HOSP,DEPT REHABIL MED GOTHENBURG SWEDEN
Titolo Testata:
European heart journal
fascicolo: 11, volume: 17, anno: 1996,
pagine: 1678 - 1685
SICI:
0195-668X(1996)17:11<1678:SCIPWC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR-MAGNETIC-RESONANCE; AEROBIC ENZYME-ACTIVITY; BLOOD-FLOW; ENERGY-METABOLISM; EXERCISE CAPACITY; ABNORMALITIES; ADAPTATIONS; ELECTROLYTES; FIBERS; WOMEN;
Keywords:
HEART FAILURE; SKELETAL MUSCLE; ANGIOTENSIN CONVERTING ENZYME INHIBITOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
M. Schaufelberger et al., "SKELETAL-MUSCLE CHANGES IN PATIENTS WITH CHRONIC HEART-FAILURE BEFOREAND AFTER TREATMENT WITH ENALAPRIL", European heart journal, 17(11), 1996, pp. 1678-1685

Abstract

To evaluate if enalapril treatment can influence skeletal muscle metabolism and histology we investigated 26 patients with congestive heartfailure and 20 normal subjects. The patients were treated with enalapril for 3 months in addition to diuretics and digitalis. Biopsies fromthe lateral vastus muscle were taken before and after treatment. Citrate synthetase, 3-hydroxyacyl-CoA dehydrogenase and phosphorylase activities were significantly decreased in the patients compared with controls. The number of capillaries per fibre and the number of capillaries surrounding each fibre were significantly decreased among patients. After 3 months of enalapril treatment functional class improved significantly. The lactate dehydrogenase activity increased whereas the oxidative enzymes did not change significantly. The type I, II and IIA fibre areas increased significantly after enalapril treatment. We conclude that patients with chronic heart failure have decreased activity of oxidative enzymes and of phosphorylase in skeletal muscle. They also have decreased capillarization in skeletal muscle. These changes were not influenced by enalapril treatment,The increase in muscle fibre areaseen after enalapril treatment could be due to increased physical activity. The cause of increased muscle lactate dehydrogenase activity after enalapril treatment needs further investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 22:54:28