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Titolo:
DEVELOPMENT OF HUMAN RENAL-FUNCTION - REFERENCE INTERVALS FOR 10 BIOCHEMICAL MARKERS IN FETAL URINE
Autore:
MULLER F; DOMMERGUES M; BUSSIERES L; LORTATJACOB S; LOIRAT C; OURY JF; AIGRAIN Y; NIAUDET P; AEGERTER P; DUMEZ Y;
Indirizzi:
UNIV PARIS 05,HOP AMBROISE PARE F-92104 BOULOGNE FRANCE HOP COCHIN F-75674 PARIS FRANCE HOP NECKER ENFANTS MALAD PARIS FRANCE HOP ROBERT DEBRE F-75019 PARIS FRANCE
Titolo Testata:
Clinical chemistry
fascicolo: 11, volume: 42, anno: 1996,
pagine: 1855 - 1860
SICI:
0009-9147(1996)42:11<1855:DOHR-R>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
BILATERAL OBSTRUCTIVE UROPATHIES; ANTENATAL DIAGNOSIS; INTERVENTION; ULTRASOUND; FETUS;
Keywords:
PRENATAL DIAGNOSIS; RENAL FUNCTION; BILATERAL OBSTRUCTIVE UROPATHY; FETAL STATUS; SODIUM; BETA-2-MICROGLOBULIN; CALCIUM; AMMONIA; CREATININE; GLUCOSE; PHOSPHORUS; CHLORIDE; UREA PROTEIN; AGE-RELATED EFFECTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
F. Muller et al., "DEVELOPMENT OF HUMAN RENAL-FUNCTION - REFERENCE INTERVALS FOR 10 BIOCHEMICAL MARKERS IN FETAL URINE", Clinical chemistry, 42(11), 1996, pp. 1855-1860

Abstract

Evaluation of fetal renal function by analysis of fetal urine sampledin utero may improve perinatal care after a prenatal diagnosis of bilateral obstructive uropathy, We provide reference intervals for 10 fetal urinary compounds and examine their variation with gestational age. Forty-one fetuses with bilateral obstructive uropathy (urine sampled between 20 and 38 weeks of gestational age) had normal, healthy valuesfor serum creatinine (less than or equal to 50 mu mol/L) at ages 1-2 years. These cases were thus assumed to represent a reasonable approximation to healthy values. Sodium and beta(2)-microglobulin concentrations significantly decreased with gestational age; calcium, ammonia, and creatinine significantly increased; glucose, phosphorus, chloride, urea, and total protein concentrations did not vary. Our results provide reference values for prenatal evaluation of fetal renal function andsuggest that glomerular filtration of macromolecules and tubular reabsorption of glucose and phosphorus are mature by 20 weeks of gestation, whereas tubular reabsorption of sodium and beta(2)-microglobulin increases progressively during the second half of gestation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:29:27