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Titolo:
GROWTH-HORMONE ASSAYS - EARLY TO LATEST TEST GENERATIONS COMPARED
Autore:
LHERMITEBALERIAUX M; COPINSCHI G; VANCAUTER E;
Indirizzi:
FREE UNIV BRUSSELS,FAC MED,EXPT MED LAB,SCH MED,CP 618,808 ROUTE LENNIK B-1070 BRUSSELS BELGIUM FREE UNIV BRUSSELS,SCH MED,CTR STUDY BIOL RHYTHMS B-1070 BRUSSELS BELGIUM UNIV CHICAGO,DEPT MED CHICAGO IL 60637
Titolo Testata:
Clinical chemistry
fascicolo: 11, volume: 42, anno: 1996,
pagine: 1789 - 1795
SICI:
0009-9147(1996)42:11<1789:GA-ETL>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GH; SECRETION; MEN; FREQUENCY; AMPLITUDE; CHILDREN; TIME;
Keywords:
INTERMETHOD COMPARISON; OBESITY; IMMUNOCHEMILUMINOMETRIC ASSAYS; IMMUNORADIOMETRIC ASSAYS; RADIOIMMUNOASSAYS; AGE-RELATED EFFECTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
M. Lhermitebaleriaux et al., "GROWTH-HORMONE ASSAYS - EARLY TO LATEST TEST GENERATIONS COMPARED", Clinical chemistry, 42(11), 1996, pp. 1789-1795

Abstract

We compared the data from four growth hormone (GH) immunoassays for analyzing 24-h GH profiles in four apparently normal subjects and four obese subjects (508 serum samples), The detection limit was 0.02 mu g/L for one immunochemiluminometric assay (ICMA), 0.1 mu g/L for two IRMAs, and 0.4 mu g/L for one RIA. All GH pulses with a peak ICMA value >1 mu g/L were detected by each of the other methods. Overall, the correlation coefficient between the values obtained with all four assays exceeded 0.90. However, for GH concentrations less than or equal to 0.25 mu g/L, acceptable concordance (r(2) greater than or equal to 0.80) was reached only between the ICMA and one IRMA; between the ICMA. and the RIA, concordance was acceptable only for GH concentrations greaterthan or equal to 10 mu g/L. In the normal subjects, the percentage ofundetectable values was 0% with the ICMA but 29% with one of the IRMAs; in obese subjects, the corresponding values were 12% and 38%.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:32:57