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Titolo:
POSSIBLE INHIBITORY EFFECT OF DIAZEPAM ON THE METABOLISM OF ZOTEPINE,AN ANTIPSYCHOTIC DRUG
Autore:
KONDO T; TANAKA O; OTANI K; MIHARA K; TOKINAGA N; KANEKO S; CHIBA K; ISHIZAKI T;
Indirizzi:
HIROSAKI UNIV,SCH MED,DEPT NEUROPSYCHIAT HIROSAKI AOMORI 036 JAPAN INT MED CTR JAPAN,RES INST,DEPT CLIN PHARMACOL TOKYO 162 JAPAN
Titolo Testata:
Psychopharmacology
fascicolo: 4, volume: 127, anno: 1996,
pagine: 311 - 314
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND TRIAL; HYDROXYLATION PHENOTYPE; S-MEPHENYTOIN; DEBRISOQUIN HYDROXYLATION; SERUM CONCENTRATIONS; GENETIC-FACTORS; PLASMA-LEVELS; HALOPERIDOL; PHARMACOKINETICS; DISPOSITION;
Keywords:
ZOTEPINE; METABOLISM; SMOKING; CYP2C19; DIAZEPAM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
T. Kondo et al., "POSSIBLE INHIBITORY EFFECT OF DIAZEPAM ON THE METABOLISM OF ZOTEPINE,AN ANTIPSYCHOTIC DRUG", Psychopharmacology, 127(4), 1996, pp. 311-314

Abstract

Effects of smoking and cytochrome P450 2C19 (CYP2C19) status on the single dose kinetics of zotepine and pharmacokinetic interaction between zotepine and diazepam were investigated. In 14 healthy volunteers, the pharmacokinetics of zotepine after a single oral 25 mg dose were compared between eight smokers and six non-smokers, or between seven extensive metabolizers (EMs) and seven poor metabolizers (PMs) of S-mephenytoin. There was no significant difference in any pharmacokinetic parameters between smokers and non-smokers, or between the EM and PM groups. In 17 patients treated with zotepine 80-340 mg/day, intra-individual changes in plasma concentrations of zotepine caused by coadministration of diazepam 10 mg/day for 2 weeks were examined. Plasma concentrations of zotepine were significantly increased after coadministration of diazepam (P < 0.05). Consequently, it is suggested that neither smoking nor CYP2C19 status affects the metabolism of zotepine. The elevation in plasma concentrations of zotepine after coadministration of diazepam may be a result of competitive inhibition of zotepine metabolismby diazepam via other isoenzyme than CYP2C19, e.g., CYP3A4.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:57:16