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Titolo:
DEFICIENCY IN NITRIC-OXIDE BIOACTIVITY IN EPICARDIAL CORONARY-ARTERIES OF CIGARETTE SMOKERS
Autore:
KUGIYAMA K; YASUE H; OHGUSHI M; MOTOYAMA T; KAWANO H; INOBE Y; HIRASHIMA O; SUGIYAMA S;
Indirizzi:
KUMAMOTO UNIV,SCH MED,DIV CARDIOL,HONJO 1-1-1 KUMAMOTO 860 JAPAN
Titolo Testata:
Journal of the American College of Cardiology
fascicolo: 5, volume: 28, anno: 1996,
pagine: 1161 - 1167
SICI:
0735-1097(1996)28:5<1161:DINBIE>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-DISEASE; RISK-FACTORS; MOLECULAR-CLONING; VARIANT ANGINA; BLOOD-FLOW; SMOKING; ENDOTHELIUM; ATHEROSCLEROSIS; ACETYLCHOLINE; INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
K. Kugiyama et al., "DEFICIENCY IN NITRIC-OXIDE BIOACTIVITY IN EPICARDIAL CORONARY-ARTERIES OF CIGARETTE SMOKERS", Journal of the American College of Cardiology, 28(5), 1996, pp. 1161-1167

Abstract

Objectives. This study sought to examine nitric oxide-mediated regulation of epicardial coronary arterial tone in cigarette smokers. Background. Cigarette smoking is a major risk factor for coronary artery disease and is highly prevalent in patients,vith coronary spastic angina. Long-term exposure to cigarette smoking has been recently reported tosuppress endothelium-dependent arterial relaxation in vivo humans. Methods. Responses of epicardial coronary artery diameter to single or combined infusion of acetylcholine and N-G-monomethyl-L-arginine (L-NMMA) into the left main coronary artery were examined in 11 current smokers and 17 nonsmokers using quantitative coronary angiography. Results. Acetylcholine dilated one-third of the proximal segments and most ofthe distal segments of coronary arteries in nonsmokers, whereas it constricted most of the proximal and distal segments in smokers. L-NMMA decreased the basal diameter of coronary arteries in nonsmokers but had minimal effect on the basal diameter in smokers. L-NMMA abolished the dilator response to acetylcholine in the coronary arteries of nonsmokers but had minimal effect on the constrictor response to acetylcholine in the arteries of smokers. The dilator response to nitroglycerin was significantly increased in the coronary arteries of smokers compared with in those of nonsmokers. The constrictor response to L-NMMA at rest was significantly correlated with the dilator response to nitroglycerin and with the diameter changes to acetylcholine in both smokers and nonsmokers. Conclusions. Nitric oxide bioactivity at rest and at acetylcholine-stimulated conditions in smokers was decreased, leading tothe supersensitivity of the artery to the dilator effect of nitroglycerin as well as the constrictor effect of acetylcholine in smokers. Cigarette smoking affects nitric oxide-mediated regulation of coronary artery tone.

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Documento generato il 27/11/20 alle ore 11:46:23