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Titolo:
PARTIAL OUTLET OBSTRUCTION INDUCES CHRONIC DISTENSION AND INCREASED STIFFNESS OF RAT URINARY-BLADDER
Autore:
DAMASER MS; ARNER A; UVELIUS B;
Indirizzi:
UNIV LUND HOSP,DEPT UROL S-22185 LUND SWEDEN LUND UNIV,DEPT PHYSIOL LUND SWEDEN
Titolo Testata:
Neurourol. urodyn.
fascicolo: 6, volume: 15, anno: 1996,
pagine: 650 - 665
SICI:
0733-2467(1996)15:6<650:POOICD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFRAVESICAL OUTFLOW OBSTRUCTION; STREPTOZOTOCIN-DIABETIC RATS; DETRUSOR INSTABILITY; PASSIVE PROPERTIES; SMOOTH-MUSCLE; GUINEA-PIG; CONTRACTILE; HYPERTROPHY; MODEL; COLLAGEN;
Keywords:
URINARY BLADDER; RAT; PASSIVE PROPERTIES; STRESS-STRETCH; PRESSURE-VOLUME; PARTIAL OUTLET OBSTRUCTION; ZERO PRESSURE VOLUME; CYSTOMETROGRAM; STEADY STATE; STEP-STRETCH; FILLING; STIFFNESS; CHRONIC DISTENSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Damaser et al., "PARTIAL OUTLET OBSTRUCTION INDUCES CHRONIC DISTENSION AND INCREASED STIFFNESS OF RAT URINARY-BLADDER", Neurourol. urodyn., 15(6), 1996, pp. 650-665

Abstract

In order to identify the passive properties of the bladder during filling, we measured cystometrograms (CMGs) of rat urinary bladders that had been outlet obstructed for 6 weeks and age-matched controls in conscious, unrestrained animals and in fully relaxed whole bladders in anorgan bath. In the organ bath, each bladder was allowed to empty passively at zero transmural pressure. The volume remaining was labelled zero pressure volume (ZPV) and was used as the reference volume to normalize contained volume, deriving wall stretch. Increased ZPV implies that the bladder contains more urine at low stresses and therefore is more distended. In awake animals, the obstructed bladder CMGs showed spontaneous contractions. The pressures between contractions were similar to those in CMGs performed in the organ bath, suggesting that passive properties determine the minimum pressures during filling in vivo. The ZPV of the obstructed and control bladders was 1.07 +/- 0.12 ml and0.07 +/- 0.01 ml, respectively. The differences were significant (P <0.01). The ZPV correlated with bladder weight and thus with degree ofhypertrophy. Under conditions when weight cannot be determined, e.g.,clinically, ZPV may provide a useful measure of the degree of chronicdistension and bladder hypertrophy. The pressure-volume curves of theobstructed bladder CMGs in vitro varied between preparations; However, when pressure-volume was converted to stress-stretch using the law of Laplace, the obstructed bladders were all significantly stiffer thanthe controls. We confirmed this result by step-stretching relaxed bladder strips. The obstructed bladder strips again demonstrated stiffer stress-stretch curves than the controls. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:29:56