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Titolo:
PHASE-II STUDY OF CHEMORADIOTHERAPY FOR ADVANCED SQUAMOUS-CELL CARCINOMA OF THE THORACIC ESOPHAGUS - 9 JAPANESE INSTITUTIONS TRIAL
Autore:
ISHIDA K; IIZUKA T; ANDO N; IDE H;
Indirizzi:
IWATE MED UNIV,SCH MED,DEPT SURG 1,19-1 UCHIMARU MORIOKA IWATE 020 JAPAN
Titolo Testata:
Japanese Journal of Clinical Oncology
fascicolo: 5, volume: 26, anno: 1996,
pagine: 310 - 315
SICI:
0368-2811(1996)26:5<310:PSOCFA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ONCOLOGY-GROUP; 5-FLUOROURACIL; RADIOTHERAPY; CHEMOTHERAPY; THERAPY; CANCER;
Keywords:
CHEMORADIOTHERAPY; ESOPHAGEAL CARCINOMA; PHASE II STUDY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
K. Ishida et al., "PHASE-II STUDY OF CHEMORADIOTHERAPY FOR ADVANCED SQUAMOUS-CELL CARCINOMA OF THE THORACIC ESOPHAGUS - 9 JAPANESE INSTITUTIONS TRIAL", Japanese Journal of Clinical Oncology, 26(5), 1996, pp. 310-315

Abstract

A phase II study of chemoradiotherapy for advanced squamous cell carcinoma of the thoracic esophagus was carried out cooperatively by nine Japanese institutions. Forty-five patients with thoracic advanced squamous cell carcinoma, who had T4 tumor or distant lymph node metastasis(M1(LYM)), were enrolled in the study for treatment with cisplatin (70 mg/m(2)) on days 1 and 36, and 5-fluorouracil infusion (700 mg/m(2))on days 1-4 and 36-39 sandwiched around external beam irradiation (60Gy over 6 weeks). Of the 45 evaluable patients, 37 (84.1%) completed the treatment. The overall response rate was 64.4%, and the complete response rate 8.9%. The median duration of response was 125.0 days far patients who achieved complete and partial response. The 50% median survival time was 215 days. There was one toxicity-related death due to radiation pneumonitis. The major form of toxicity exceeding grade 2 was myelosuppression and anorexia, but grade 4 toxicity was also observed (2 pulmonary, 1 severe hypoxemia, 1 severe cardiac failure and 1 mental disturbance). The results showed that this form of chemoradiotherapy had a satisfactory effect and might be useful for treatment of inoperable advanced esophageal cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 04:24:36