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Titolo:
INHIBITORY AVOIDANCE IMPAIRMENTS INDUCED BY INTRAAMYGDALA PROPRANOLOLARE REVERSED BY GLUTAMATE BUT NOT GLUCOSE
Autore:
LENNARTZ RC; HELLEMS KL; MOOK ER; GOLD PE;
Indirizzi:
UNIV VIRGINIA,DEPT PSYCHOL,GILMER HALL CHARLOTTESVILLE VA 22903 UNIV VIRGINIA,DEPT PSYCHOL CHARLOTTESVILLE VA 22903
Titolo Testata:
Behavioral neuroscience
fascicolo: 5, volume: 110, anno: 1996,
pagine: 1033 - 1039
SICI:
0735-7044(1996)110:5<1033:IAIIBI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
FEAR-POTENTIATED STARTLE; NORADRENALINE TURNOVER; NORADRENERGIC INFLUENCES; SPONTANEOUS-ALTERNATION; PSYCHOLOGICAL STRESS; RECEPTOR ANTAGONISTS; MORPHINE INJECTIONS; MEMORY STORAGE; BRAIN-REGIONS; MEDIAL SEPTUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
R.C. Lennartz et al., "INHIBITORY AVOIDANCE IMPAIRMENTS INDUCED BY INTRAAMYGDALA PROPRANOLOLARE REVERSED BY GLUTAMATE BUT NOT GLUCOSE", Behavioral neuroscience, 110(5), 1996, pp. 1033-1039

Abstract

Both systemic and central injections of glucose can enhance memory. For example, glucose reverses impairments on inhibitory avoidance resulting from intra-amygdala injections of morphine. The present experiment investigated the ability of glucose to reverse memory impairments resulting from intra-amygdala injections of propranolol, a beta-noradrenergic antagonist. Pretraining administration of 10 mu g propranolol significantly reduced inhibitory avoidance retention latencies but had no effect on performance in a spontaneous alternation task. Coadministration of glucose into the amygdala at 3 doses (1.5, 3.0, and 6.0 mu g)did not reverse the propranolol-induced inhibitory avoidance deficits. However, coadministration of 2.5 mu g of glutamate with the propranolol did reverse these deficits. The ability of glucose to reverse impairments following intra-amygdala injections of morphine but not propranolol may reflect the neurotransmitter system or systems through whichglucose exerts its effects.

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Documento generato il 08/07/20 alle ore 05:55:56