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Titolo:
EFFECTS OF EXCITOTOXIC LESIONS OF THE CENTRAL AMYGDALOID NUCLEUS ON THE POTENTIATION OF REWARD-RELATED STIMULI BY INTRAACCUMBENS AMPHETAMINE
Autore:
ROBLEDO P; ROBBINS TW; EVERITT BJ;
Indirizzi:
UNIV CAMBRIDGE,DEPT EXPT PSYCHOL,DOWNING ST CAMBRIDGE CB2 3EB ENGLAND UNIV CAMBRIDGE,DEPT EXPT PSYCHOL CAMBRIDGE CB2 3EB ENGLAND
Titolo Testata:
Behavioral neuroscience
fascicolo: 5, volume: 110, anno: 1996,
pagine: 981 - 990
SICI:
0735-7044(1996)110:5<981:EOELOT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONDITIONED REINFORCEMENT; DOPAMINE-RECEPTORS; BASAL FOREBRAIN; 6-HYDROXYDOPAMINE LESIONS; HORSERADISH-PEROXIDASE; SUBSTANTIA INNOMINATA; VENTRAL SUBICULUM; PREFRONTAL CORTEX; EXTENDED AMYGDALA; STARTLE PARADIGM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
P. Robledo et al., "EFFECTS OF EXCITOTOXIC LESIONS OF THE CENTRAL AMYGDALOID NUCLEUS ON THE POTENTIATION OF REWARD-RELATED STIMULI BY INTRAACCUMBENS AMPHETAMINE", Behavioral neuroscience, 110(5), 1996, pp. 981-990

Abstract

The present study examined the effects of lesions of the central nucleus of the amygdala (CeA) on the acquisition of a new response with conditioned reinforcement (CR) and its potentiation by intra-accumbens infusions of d-amphetamine (1, 3, 10, and 20 mu g/mu l). Rats were trained to associate a light-plus-noise compound stimulus with the availability of a sucrose solution before receiving both bilateral ibotenic acid lesions of the CeA and cannulas implanted above the nucleus accumbens. Lesions of the central nucleus did not impair the performance of positively reinforced discriminated approach, nor did they impair the acquisition of a new response with conditioned reinforcement. However,the potentiation of responding with CR following intraaccumbens amphetamine was blocked in lesioned animals. These results are discussed interms of the possible interactions between associative mechanisms in the amygdala and the mesolimbic dopamine projection.

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Documento generato il 26/01/20 alle ore 00:55:53