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Titolo:
ANTIPHOSPHOLIPID ANTIBODIES AND ATHEROSCLEROSIS
Autore:
VAARALA O;
Indirizzi:
NATL PUBL HLTH INST,DEPT BIOCHEM,MANNERHEIMINTIE 116 SF-00300 HELSINKI FINLAND
Titolo Testata:
Lupus
fascicolo: 5, volume: 5, anno: 1996,
pagine: 442 - 447
SICI:
0961-2033(1996)5:5<442:AAAA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; LOW-DENSITY-LIPOPROTEIN; HUMAN MONOCYTE-MACROPHAGES; SMOOTH-MUSCLE CELLS; ANTICARDIOLIPIN ANTIBODIES; MYOCARDIAL-INFARCTION; CAROTID ATHEROSCLEROSIS; OXIDATIVE MODIFICATION; T-CELLS; AUTOANTIBODIES;
Keywords:
THROMBOSIS; ATHEROSCLEROSIS; ANTIPHOSPHOLIPID ANTIBODIES; OXIDIZED LOW-DENSITY LIPOPROTEIN; PROTHROMBIN; BETA(2)-GLYCOPROTEIN I;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
O. Vaarala, "ANTIPHOSPHOLIPID ANTIBODIES AND ATHEROSCLEROSIS", Lupus, 5(5), 1996, pp. 442-447

Abstract

The family of antiphospholipid antibodies includes antibodies bindingto cardiolipin in serological test for syphilis, antibodies prolonging the clotting lime in lupus anticoagulant test, antibodies reacting with plasma phospholipid-binding proteins, such as beta(2)-glycoproteinI and prothrombin, and antibodies binding to oxidized low-density lipoprotein (LDL). Antiphospholipid antibodies are traditionally associated with arterial and venous thrombosis in patients with primary or secondary antiphospholipid syndrome, The recent studies, especially thoseon patients with myocardial infarction, extend the concept of antiphospholipid antibodies, and suggest that they play a role also in atherosclerosis. Based on the clinical studies and immunological findings, it seems that the differences in the specificity of antiphospholipid antibodies may reflect to their pathogenetic mechanisms and, finally, totheir clinical consequences. The present review suggests that antibodies to oxidized LDL may not interfere directly with blood coagulation,but seem to have importance in the inflammation of the vessel wall inatherosclerosis and in vasculitis. Instead, antibodies to beta(2)-glycoprotein I and to prothrombin show a closer association with thrombosis. It is possible that in the atherosclerotic plaque, the plasma proteins, such as beta(2)-glycoprotein I or prothrombin, are bound to the endothelial surface and antibodies ro cryptic epitopes revealed in these proteins are induced. These antibodies may contribute to the formation of atherosclerotic thrombosis by changing the balance of haemostasis towards hypercoagulative state.

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Documento generato il 19/02/20 alle ore 15:21:45