Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ANTITHROMBIN-III INHIBITS MESANGIAL CELL-PROLIFERATION
Autore:
PAHL MV; VAZIRI ND; OVEISI F; WANG J; DING YX;
Indirizzi:
UNIV CALIF IRVINE,IRVINE MED CTR,DEPT MED,DIV NEPHROL ORANGE CA 92668
Titolo Testata:
Journal of the American Society of Nephrology
fascicolo: 10, volume: 7, anno: 1996,
pagine: 2249 - 2253
SICI:
1046-6673(1996)7:10<2249:AIMC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; THROMBIN; HEPARIN; CULTURE; GROWTH; MODULATION; INDUCTION; BINDING;
Keywords:
GLOMERULONEPHRITIS; THROMBIN; HEPARIN; ANTICOAGULANT; MESANGIAL CELL GROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M.V. Pahl et al., "ANTITHROMBIN-III INHIBITS MESANGIAL CELL-PROLIFERATION", Journal of the American Society of Nephrology, 7(10), 1996, pp. 2249-2253

Abstract

Thrombin stimulates and heparin and heparan sulfate inhibit mesangialcell proliferation, In addition, heparin has been shown to inhibit thrombin-stimulated smooth muscle cell proliferation. The anticoagulant action of heparin is mediated by antithrombin III. This study investigated whether heparin's antiproliferative action is also mediated by antithrombin III, To this end, the effect of antithrombin III on thrombin-stimulated mesangial cell growth was examined. As expected, thrombinstimulated DNA synthesis and cell growth in cultured human mesangial cells. The effect of thrombin on DNA synthesis and mesangial cell proliferation was inhibited by standard heparin and antithrombin III, separately or together, The magnitude of the inhibitory action of antithrombin III was equal to that of equimolar concentrations of heparin and that observed with the combination of the two. Experiments carried outin serum (hence antithrombin III)-free medium revealed that heparin'sinhibitory effects are independent of antithrombin III. It was concluded that antithrombin III, an endogenous inhibitor of thrombin's coagulant activity, is an equally effective inhibitor of thrombin's mitogenic action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 23:18:31