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Titolo:
ANTIMALARIAL-DRUGS INHIBIT THE PHAGOCYTOSIS OF ERYTHROCYTES INFECTED WITH PLASMODIUM-FALCIPARUM
Autore:
SHALMIEV G; KRUGLIAK M; TURRINI F; GINSBURG H;
Indirizzi:
HEBREW UNIV JERUSALEM,INST LIFE SCI,DEPT BIOL CHEM IL-91904 JERUSALEMISRAEL HEBREW UNIV JERUSALEM,INST LIFE SCI,DEPT BIOL CHEM IL-91904 JERUSALEMISRAEL UNIV TURIN,DEPT GENET BIOL & MED CHEM I-10126 TURIN ITALY
Titolo Testata:
Transactions of the Royal Society of Tropical Medicine and Hygiene
fascicolo: 5, volume: 90, anno: 1996,
pagine: 558 - 562
SICI:
0035-9203(1996)90:5<558:AITPOE>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
RED-BLOOD-CELLS; MEMBRANE-PROTEINS; SENESCENT ANTIGEN; HUMAN MONOCYTES; BAND-3 PROTEIN; HUMAN MALARIA; CYTOADHERENCE; INVOLVEMENT; THALASSEMIA; EXPRESSION;
Keywords:
MALARIA; PLASMODIUM FALCIPARUM; PHAGOCYTOSIS IN VITRO; INHIBITION BY DRUGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
G. Shalmiev et al., "ANTIMALARIAL-DRUGS INHIBIT THE PHAGOCYTOSIS OF ERYTHROCYTES INFECTED WITH PLASMODIUM-FALCIPARUM", Transactions of the Royal Society of Tropical Medicine and Hygiene, 90(5), 1996, pp. 558-562

Abstract

Phagocytic cells constitute the first line of defence against malarial parasites. They perform their role by delivering oxidative radicals and by phagocytosing infected red blood cells (IRBC). Phagocytosis is mediated by antibody binding to clustered band 3 antigen in the IRBC membrane and activation of the alternative complement pathway. In this study we showed that treatment of IRBC containing Plasmodium falciparum with therapeutically-relevant concentrations of antimalarial drugs considerably reduced the binding of immunoglobulin G (IgG) to, and the phagocytosis of, IRBC. Opsonization of IRBC by fresh serum before drugtreatment prevented this inhibitory action of drugs. Removal of the drug restored IgG binding and the phagocytic susceptibility of IRBC in a time-dependent fashion. Direct measurement of the effect of chloroquine on the clustering of band 3 in IRBC, however, failed to reveal anydisruption of the aggregation. We conclude that antimalarial drugs are able to alter, by an as yet unresolved mechanism, the affinity of IgG to clustered band 3. This affinity of IRBC seems to be determined bya dynamic process that depends on the metabolic activity of the parasite.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 07:09:55